Pharmacological comparison of the effect of ibogaine and 18‐methoxycoronaridine on isolated smooth muscle from the rat and guinea‐pig

Ibogaine and 18‐methoxycoronaridine are naturally occurring alkaloids reported to possess antiaddictive properties in several models of drug dependence. We have examined their effect at μ‐opioid receptors regulating neurogenic contractions of several smooth muscle preparations and also against spont...

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Veröffentlicht in:	British journal of pharmacology 2000-04, Vol.129 (8), p.1561-1568
Hauptverfasser:	Mundey, M K, Blaylock, N A, Mason, R, Glick, S D, Maisonneuve, I M, Wilson, V G
Format:	Artikel
Sprache:	eng
Schlagworte:	18‐methoxycoronaridine Animals Biological and medical sciences Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists - pharmacology Guinea Pigs guinea‐pig isolated ileum Ibogaine Ibogaine - analogs & derivatives Ibogaine - pharmacology Ileum - drug effects Ileum - physiology Male Medical sciences Muscle Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Portal Vein - drug effects Portal Vein - physiology purinergic transmission rat portal vein rat vas deferens Rats Urinary Bladder - drug effects Urinary Bladder - physiology Vas Deferens - drug effects Vas Deferens - physiology μ‐opioid receptors
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