Evidence that rat hepatocytes co‐express functional P2Y1 and P2Y2 receptors

Previous studies have indicated the expression of multiple P2Y receptors by rat hepatocytes although they have not been identified. Here we show by reverse transcriptase‐polymerase chain reaction (RT–PCR) that rat hepatocytes express mRNA encoding all of the four cloned rat P2Y receptors (P2Y1, P2Y2...

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Veröffentlicht in:	British journal of pharmacology 2000-02, Vol.129 (4), p.764-770
Hauptverfasser:	Dixon, C Jane, Woods, Niall M, Webb, Tania E, Green, Anne K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adenosine Triphosphate - pharmacology ADP Animals ATP Biological and medical sciences Calcium - metabolism calcium transients DNA, Complementary - genetics DNA, Complementary - metabolism intracellular free calcium concentration Liver - drug effects Liver - metabolism Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors P2Y receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments PPADS Pyridoxal Phosphate - analogs & derivatives Pyridoxal Phosphate - pharmacology Rat hepatocytes Rats Rats, Wistar Receptors, Purinergic P2 - biosynthesis Receptors, Purinergic P2 - classification Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - physiology Receptors, Purinergic P2Y1 Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics RT–PCR suramin Suramin - pharmacology Uridine Diphosphate - pharmacology Uridine Triphosphate - pharmacology UTP
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