Vasodilator effects of sodium nitroprusside, levcromakalim and their combination in isolated rat aorta

The endothelial modulation of the relaxant responses to the nitric oxide (NO) donor sodium nitroprusside (SNP) and the KATP channel opener levcromakalim (LEM) and the interactions between these agents were analysed in isolated rat aorta. LEM‐induced relaxation was unchanged by endothelium removal or...

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Veröffentlicht in:	British journal of pharmacology 1999-12, Vol.128 (7), p.1419-1426
Hauptverfasser:	Pérez‐Vizcaíno, Francisco, Cogolludo, Angel L, Zaragozá‐Arnáez, Francisco, Fajardo, Susana, Ibarra, Manuel, López‐López, J G, Tamargo, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - physiology Animals Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Aorta, Thoracic - physiology Biological and medical sciences Cardiovascular system Cromakalim - pharmacology Cyclic GMP - antagonists & inhibitors Cyclic GMP - biosynthesis Cyclic GMP - physiology Drug Combinations endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiology In Vitro Techniques isobolographic analysis levcromakalim Male Medical sciences Muscle Relaxation - drug effects Muscle Relaxation - physiology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiology Nitric Oxide - antagonists & inhibitors Nitric Oxide - physiology Nitric Oxide Donors - pharmacology Nitroprusside Nitroprusside - pharmacology Pharmacology. Drug treatments Potassium Channels - drug effects Potassium Channels - physiology rat aorta Rats Rats, Wistar Vascular wall Vasodilator Agents - pharmacology
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