Continued morphine modulation of calcium channel currents in acutely isolated locus coeruleus neurons from morphine‐dependent rats

The actions of the opioid agonists morphine and methionine‐enkephalin (met‐enkephalin) on the calcium channel currents (IBa) of acutely isolated locus coeruleus (LC) neurons from morphine‐dependent and vehicle‐treated rats were examined using whole cell patch clamp techniques. In LC neurons maintain...

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Veröffentlicht in:	British journal of pharmacology 1999-12, Vol.128 (7), p.1561-1569
Hauptverfasser:	Connor, Mark, Borgland, Stephanie L, Christie, Macdonald J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Animals Biological and medical sciences Calcium Channel Blockers - pharmacology calcium channels Calcium Channels - biosynthesis Calcium Channels - metabolism Calcium Channels - physiology Enkephalin, Methionine - pharmacology locus coeruleus Locus Coeruleus - cytology Locus Coeruleus - drug effects Locus Coeruleus - metabolism Locus Coeruleus - physiology Male Medical sciences Membrane Potentials - drug effects Membrane Potentials - physiology met‐enkephalin Morphine Morphine - pharmacology Morphine Dependence - metabolism Morphine Dependence - physiopathology Naloxone - pharmacology Narcotic Antagonists - pharmacology Neurons - drug effects Neurons - physiology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors opioid dependence opioid tolerance Patch-Clamp Techniques Peptide Fragments Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Peptides - pharmacology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Receptors, Opioid, mu - antagonists & inhibitors Receptors, Opioid, mu - metabolism Receptors, Opioid, mu - physiology Somatostatin withdrawal
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