Activity profiles of dalargin and its analogues in μ‐, δ‐ and κ‐opioid receptor selective bioassays

To elucidate the structural features ensuring action of [D‐Ala2, Leu5]‐enkephalyl‐Arg (dalargin), a series of dalargin analogues were tested for their effectiveness in depressing electrically‐evoked contractions of the guinea‐pig myenteric plexus‐longitudinal muscle preparations (μ‐ and κ‐opioid rec...

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Veröffentlicht in:	British journal of pharmacology 1999-10, Vol.128 (3), p.569-576
Hauptverfasser:	Pencheva, Nevena, Pospišek, Jan, Hauzerova, Linda, Barth, Tomislav, Milanov, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Biological Assay Cricetinae dalargin Digestive system Enkephalin, Leucine-2-Alanine - analogs & derivatives Enkephalin, Leucine-2-Alanine - chemistry Enkephalin, Leucine-2-Alanine - pharmacology Guinea Pigs guinea‐pig ileum hamster vas deferens In Vitro Techniques Male Medical sciences Mesocricetus Mice mouse vas deferens myenteric plexus Myenteric Plexus - drug effects Naloxone - pharmacology Narcotic Antagonists - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Opioid peptides peptide analogues Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Rabbits rat vas deferens Rats Rats, Wistar Receptors, Opioid - drug effects Vas Deferens - drug effects δ‐receptor μ‐receptor
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