Resiniferatoxin‐type phorboid vanilloids display capsaicin‐like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1

Although the cloned rat vanilloid receptor VR1 appears to account for both receptor binding and calcium uptake, the identification of vanilloids selective for one or the other response is of importance because these ligands may induce distinct patterns of biological activities. Phorbol 12,13‐didecan...

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Veröffentlicht in:	British journal of pharmacology 1999-09, Vol.128 (2), p.428-434
Hauptverfasser:	Szallasi, A, Szabó, T, Bíró, T, Modarres, S, Blumberg, P M, Krause, J E, Cortright, D N, Appendino, G
Format:	Artikel
Sprache:	eng
Schlagworte:	[3H]‐resiniferatoxin binding Animals Calcium - metabolism capsaicin Capsaicin - pharmacology capsaicin‐type vanilloid pharmacology Cell Membrane - metabolism CHO Cells Cloning, Molecular Cricetinae Diterpenes - pharmacology DNA, Complementary - biosynthesis DNA, Complementary - genetics Female Fluorescent Dyes Ganglia, Spinal - cytology Ganglia, Spinal - drug effects native vanilloid receptors Neurotoxins - pharmacology phorboid vanilloids Phorbol 12,13‐didecanoate 20‐homovanillate Rats Rats, Sprague-Dawley Receptors, Drug - drug effects Receptors, Drug - genetics vanilloid receptor subtype 1 (VR1) VR1‐transfected CHO cells
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