Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO‐K1 cells expressing human angiotensin II AT1 receptors

CHO‐K1 cells that were stably transfected with the gene for the human AT1 receptor (CHO‐AT1 cells) were used for pharmacological studies of non‐peptide AT1 receptor antagonists. In the presence of 10 mM LiCl, angiotensin II caused a concentration‐dependent and long‐lasting increase of inositol phosp...

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Veröffentlicht in:	British journal of pharmacology 1999-02, Vol.126 (4), p.1057-1065
Hauptverfasser:	Vanderheyden, P M L, Fierens, F L P, De Backer, J P, Fraeyman, N, Vauquelin, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Angiotensin II - metabolism Angiotensin II - pharmacology Angiotensin Receptor Antagonists Animals antagonist Antihypertensive agents AT1 receptors Benzimidazoles - pharmacology Biological and medical sciences calcium transients candesartan Cardiovascular system Cattle CHO Cells Cricetinae Dose-Response Relationship, Drug extracellular acidification Humans Inositol Phosphates - metabolism inositol trisphosphate insurmountable Medical sciences Pharmacology. Drug treatments Receptors, Angiotensin - metabolism Recombinant Proteins - antagonists & inhibitors surmountable Tetrazoles - pharmacology Transfection
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