Inhibition of serum and transforming growth factor beta (TGF‐β1)‐induced DNA synthesis in confluent airway smooth muscle by heparin

1 Airway remodelling occurs in asthma and involves an increase in airway smooth muscle mass through cell proliferation and hypertrophy. Increased eosinophil density in the airways is a feature of asthma. Eosinophils exhibiting activation in the airways of asthmatics also exhibit increased expression...

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Veröffentlicht in:	British journal of pharmacology 1998-10, Vol.125 (4), p.599-606
Hauptverfasser:	Okona‐Mensah, K B, Shittu, E, Page, C, Costello, J, Kilfeather, S A
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Airway Animals Asthma - physiopathology Biological and medical sciences Blood Physiological Phenomena Cattle Cell Division - drug effects Cells, Cultured DNA synthesis Dose-Response Relationship, Drug epidermal growth factor Epidermal Growth Factor - pharmacology Fundamental and applied biological sciences. Psychology glycosaminoglycans heparin Heparin - pharmacology mitogenesis Muscle, Smooth - drug effects Muscle, Smooth - metabolism Nucleic Acid Synthesis Inhibitors Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics smooth muscle tissue remodelling Trachea - metabolism transforming growth factor beta Transforming Growth Factor beta - pharmacology Vertebrates: respiratory system
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