Interaction of musleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing

In myotonic dystrophy (DM1), both inactivation of muscleblind proteins and increased levels of CUG‐BP1 are reported. These events have been shown to contribute independently to aberrant splicing of a subset RNAs. We demonstrate that steady‐state levels of the splice regulator, hnRNP H, are elevated...

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Veröffentlicht in:	The EMBO journal 2006-09, Vol.25 (18), p.4271-4283
Hauptverfasser:	Paul, Sharan, Dansithong, Warunee, Kim, Dongho, Rossi, John, Webster, Nicholas JG, Comai, Lucio, Reddy, Sita
Format:	Artikel
Sprache:	eng
Schlagworte:	CUG-BP1 Dystrophy EMBO24 EMBO36 Gene expression hnRNP H Inactivation Molecular biology muscleblind Muscular dystrophy myotonic dystrophy 1 Proteins Ribonucleic acid RNA splicing
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