Unequal Sister Chromatid and Homolog Recombination at a Tandem Duplication of the a1 Locus in Maize
Tandemly arrayed duplicate genes are prevalent. The maize A1-b haplotype is a tandem duplication that consists of the components, alpha and beta. The rate of meiotic unequal recombination at A1-b is ninefold higher when a homolog is present than when it is absent (i.e., hemizygote). When a sequence...
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| Veröffentlicht in: | Genetics (Austin) 2006-08, Vol.173 (4), p.2211-2226 |
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| creator | Yandeau-Nelson, Marna D Xia, Yiji Li, Jin Neuffer, M. Gerald Schnable, Patrick S |
| description | Tandemly arrayed duplicate genes are prevalent. The maize A1-b haplotype is a tandem duplication that consists of the components, alpha and beta. The rate of meiotic unequal recombination at A1-b is ninefold higher when a homolog is present than when it is absent (i.e., hemizygote). When a sequence heterologous homolog is available, 94% of recombinants (264/281) are generated via recombination with the homolog rather than with the sister chromatid. In addition, 83% (220/264) of homolog recombination events involved alpha rather than beta. These results indicate that: (1) the homolog is the preferred template for unequal recombination and (2) pairing of the duplicated segments with the homolog does not occur randomly but instead favors a particular configuration. The choice of recombination template (i.e., homolog vs. sister chromatid) affects the distribution of recombination breakpoints within a1. Rates of unequal recombination at A1-b are similar to the rate of recombination between nonduplicated a1 alleles. Unequal recombination is therefore common and is likely to be responsible for the generation of genetic variability, even within inbred lines. |
| doi_str_mv | 10.1534/genetics.105.052712 |
| format | Article |
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Gerald ; Schnable, Patrick S</creator><creatorcontrib>Yandeau-Nelson, Marna D ; Xia, Yiji ; Li, Jin ; Neuffer, M. Gerald ; Schnable, Patrick S</creatorcontrib><description>Tandemly arrayed duplicate genes are prevalent. The maize A1-b haplotype is a tandem duplication that consists of the components, alpha and beta. The rate of meiotic unequal recombination at A1-b is ninefold higher when a homolog is present than when it is absent (i.e., hemizygote). When a sequence heterologous homolog is available, 94% of recombinants (264/281) are generated via recombination with the homolog rather than with the sister chromatid. In addition, 83% (220/264) of homolog recombination events involved alpha rather than beta. These results indicate that: (1) the homolog is the preferred template for unequal recombination and (2) pairing of the duplicated segments with the homolog does not occur randomly but instead favors a particular configuration. The choice of recombination template (i.e., homolog vs. sister chromatid) affects the distribution of recombination breakpoints within a1. Rates of unequal recombination at A1-b are similar to the rate of recombination between nonduplicated a1 alleles. Unequal recombination is therefore common and is likely to be responsible for the generation of genetic variability, even within inbred lines.</description><identifier>ISSN: 0016-6731</identifier><identifier>ISSN: 1943-2631</identifier><identifier>EISSN: 1943-2631</identifier><identifier>DOI: 10.1534/genetics.105.052712</identifier><identifier>PMID: 16751673</identifier><identifier>CODEN: GENTAE</identifier><language>eng</language><publisher>United States: Genetics Soc America</publisher><subject>Base Sequence ; Cell division ; Chromatids - genetics ; Chromosomes, Plant - genetics ; Components ; Copy ; Genes ; Genetics ; Genomics ; Investigations ; Meiosis - genetics ; Molecular Sequence Data ; Mutation ; Plant resistance ; Quantitative Trait Loci - genetics ; Recombination, Genetic ; Ribosomal DNA ; Zea mays ; Zea mays - genetics</subject><ispartof>Genetics (Austin), 2006-08, Vol.173 (4), p.2211-2226</ispartof><rights>Copyright Genetics Society of America Aug 2006</rights><rights>Copyright © 2006 by the Genetics Society of America 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-c93fc7aac21f6c3ab044a858ab77f8a7e217c6a7ea4372a75abd75a9645a021a3</citedby><cites>FETCH-LOGICAL-c524t-c93fc7aac21f6c3ab044a858ab77f8a7e217c6a7ea4372a75abd75a9645a021a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16751673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yandeau-Nelson, Marna D</creatorcontrib><creatorcontrib>Xia, Yiji</creatorcontrib><creatorcontrib>Li, Jin</creatorcontrib><creatorcontrib>Neuffer, M. Gerald</creatorcontrib><creatorcontrib>Schnable, Patrick S</creatorcontrib><title>Unequal Sister Chromatid and Homolog Recombination at a Tandem Duplication of the a1 Locus in Maize</title><title>Genetics (Austin)</title><addtitle>Genetics</addtitle><description>Tandemly arrayed duplicate genes are prevalent. The maize A1-b haplotype is a tandem duplication that consists of the components, alpha and beta. The rate of meiotic unequal recombination at A1-b is ninefold higher when a homolog is present than when it is absent (i.e., hemizygote). When a sequence heterologous homolog is available, 94% of recombinants (264/281) are generated via recombination with the homolog rather than with the sister chromatid. In addition, 83% (220/264) of homolog recombination events involved alpha rather than beta. These results indicate that: (1) the homolog is the preferred template for unequal recombination and (2) pairing of the duplicated segments with the homolog does not occur randomly but instead favors a particular configuration. The choice of recombination template (i.e., homolog vs. sister chromatid) affects the distribution of recombination breakpoints within a1. Rates of unequal recombination at A1-b are similar to the rate of recombination between nonduplicated a1 alleles. Unequal recombination is therefore common and is likely to be responsible for the generation of genetic variability, even within inbred lines.</description><subject>Base Sequence</subject><subject>Cell division</subject><subject>Chromatids - genetics</subject><subject>Chromosomes, Plant - genetics</subject><subject>Components</subject><subject>Copy</subject><subject>Genes</subject><subject>Genetics</subject><subject>Genomics</subject><subject>Investigations</subject><subject>Meiosis - genetics</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Plant resistance</subject><subject>Quantitative Trait Loci - genetics</subject><subject>Recombination, Genetic</subject><subject>Ribosomal DNA</subject><subject>Zea mays</subject><subject>Zea mays - genetics</subject><issn>0016-6731</issn><issn>1943-2631</issn><issn>1943-2631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFktuKFDEQhhtR3HH1CQQJXuhVj6kcu2-EZTysMCLo7nWozqSns3Qns51uB316Iz0ebzYhVVD11Q8p_qJ4CnQNkotXexfc5G1aA5VrKpkGdq9YQS14yRSH-8WKUlCl0hzOikcp3VBKVS2rh8UZKC3z46vCXgd3O2NPvvg0uZFsujEOOPkdwbAjl3GIfdyTz87GofEhN2IgOBEkV7nvBvJmPvTeLvXYkqlzBIFso50T8YF8RP_dPS4etNgn9-SUz4vrd2-vNpfl9tP7D5uLbWklE1Npa95ajWgZtMpybKgQWMkKG63bCrVjoK3KGQXXDLXEZpdDrYREygD5efF60T3MzeB21oVpxN4cRj_g-M1E9ObfTvCd2cevBqSqNa2zwIuTwBhvZ5cmM_hkXd9jcHFORlW6ppXQd4JQyxp4PneDnOWrMvj8P_AmzmPI6zIMBHCpFMsQXyA7xpRG1_7-G1Dz0xPmlydyQZrFE3nq2d9r-TNzMkEGXi5A5_fd0Y_OpAH7PuNgjscjaG6EYQyA_wAoNcJ1</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Yandeau-Nelson, Marna D</creator><creator>Xia, Yiji</creator><creator>Li, Jin</creator><creator>Neuffer, M. 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Gerald</au><au>Schnable, Patrick S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unequal Sister Chromatid and Homolog Recombination at a Tandem Duplication of the a1 Locus in Maize</atitle><jtitle>Genetics (Austin)</jtitle><addtitle>Genetics</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>173</volume><issue>4</issue><spage>2211</spage><epage>2226</epage><pages>2211-2226</pages><issn>0016-6731</issn><issn>1943-2631</issn><eissn>1943-2631</eissn><coden>GENTAE</coden><abstract>Tandemly arrayed duplicate genes are prevalent. The maize A1-b haplotype is a tandem duplication that consists of the components, alpha and beta. The rate of meiotic unequal recombination at A1-b is ninefold higher when a homolog is present than when it is absent (i.e., hemizygote). When a sequence heterologous homolog is available, 94% of recombinants (264/281) are generated via recombination with the homolog rather than with the sister chromatid. In addition, 83% (220/264) of homolog recombination events involved alpha rather than beta. These results indicate that: (1) the homolog is the preferred template for unequal recombination and (2) pairing of the duplicated segments with the homolog does not occur randomly but instead favors a particular configuration. The choice of recombination template (i.e., homolog vs. sister chromatid) affects the distribution of recombination breakpoints within a1. Rates of unequal recombination at A1-b are similar to the rate of recombination between nonduplicated a1 alleles. Unequal recombination is therefore common and is likely to be responsible for the generation of genetic variability, even within inbred lines.</abstract><cop>United States</cop><pub>Genetics Soc America</pub><pmid>16751673</pmid><doi>10.1534/genetics.105.052712</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Genetics (Austin), 2006-08, Vol.173 (4), p.2211-2226 |
| issn | 0016-6731 1943-2631 1943-2631 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Base Sequence Cell division Chromatids - genetics Chromosomes, Plant - genetics Components Copy Genes Genetics Genomics Investigations Meiosis - genetics Molecular Sequence Data Mutation Plant resistance Quantitative Trait Loci - genetics Recombination, Genetic Ribosomal DNA Zea mays Zea mays - genetics |
| title | Unequal Sister Chromatid and Homolog Recombination at a Tandem Duplication of the a1 Locus in Maize |
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