Surveys of Workers Occupationally Exposed to PCBs and of Yusho Patients
Surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of thread or of paint, and of Yusho patients were carried out from 1973 to 1982. PCB concentrations in the plasma of the workers ranged from 2 to 521 ppb, and some showed higher PCB levels in the plasma t...
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description | Surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of thread or of paint, and of Yusho patients were carried out from 1973 to 1982. PCB concentrations in the plasma of the workers ranged from 2 to 521 ppb, and some showed higher PCB levels in the plasma than typical Japanese Yusho patients. Gas chromatographic patterns of plasma PCBs of the workers with high PCB levels were shown to match the patterns of the PCBs to which they had been exposed in the workplace. Japanese Yusho children showed remarkable decrease with time, but no such decrease was observed in the Yusho adults and the workers. Polychlorinated quaterphenyls (PCQs) were detected in the blood of typical Japanese and Taiwanese Yusho patients, but PCQ levels in the plasma of the workers were below the detection limit of 0.02 ppb. Clinical findings and subjective complaints of the workers were usually slight compared with typical Yusho patients, though some of them had mild dermal manifestations and their PCB levels were suspected to be related to serum triglyceride values. On the basis of these results, we discussed the relationship between the health status of the subjects and their contamination with PCBs or related compounds. |
doi_str_mv | 10.2307/3429880 |
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PCB concentrations in the plasma of the workers ranged from 2 to 521 ppb, and some showed higher PCB levels in the plasma than typical Japanese Yusho patients. Gas chromatographic patterns of plasma PCBs of the workers with high PCB levels were shown to match the patterns of the PCBs to which they had been exposed in the workplace. Japanese Yusho children showed remarkable decrease with time, but no such decrease was observed in the Yusho adults and the workers. Polychlorinated quaterphenyls (PCQs) were detected in the blood of typical Japanese and Taiwanese Yusho patients, but PCQ levels in the plasma of the workers were below the detection limit of 0.02 ppb. Clinical findings and subjective complaints of the workers were usually slight compared with typical Yusho patients, though some of them had mild dermal manifestations and their PCB levels were suspected to be related to serum triglyceride values. On the basis of these results, we discussed the relationship between the health status of the subjects and their contamination with PCBs or related compounds.</description><identifier>ISSN: 0091-6765</identifier><identifier>DOI: 10.2307/3429880</identifier><identifier>PMID: 3921371</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>560306 - Chemicals Metabolism & Toxicology- Man- (-1987) ; Adult ; AGE DEPENDENCE ; AROMATICS ; ASIA ; BENZOFURANS ; Benzofurans - blood ; BIOLOGICAL MATERIALS ; BLOOD ; Blood plasma ; BODY FLUIDS ; CEREALS ; CHEMICAL INDUSTRY ; Child ; Children ; CHLORINATED AROMATIC HYDROCARBONS ; Chlorobenzenes - blood ; Cholesterols ; Dibenzofurans, Polychlorinated ; DISTRIBUTION ; Food Contamination ; FURANS ; GRASS ; HALOGENATED AROMATIC HYDROCARBONS ; HAZARDS ; HEALTH HAZARDS ; HETEROCYCLIC COMPOUNDS ; Humans ; INDUSTRY ; JAPAN ; MATERIALS ; Occupational and Environmental Exposures ; OCCUPATIONAL DISEASES ; Occupational Diseases - chemically induced ; OCCUPATIONAL EXPOSURE ; OILS ; Oils - poisoning ; ORGANIC CHLORINE COMPOUNDS ; ORGANIC COMPOUNDS ; ORGANIC HALOGEN COMPOUNDS ; ORGANIC OXYGEN COMPOUNDS ; Oryza - poisoning ; OTHER ORGANIC COMPOUNDS ; Patient assessment ; PATIENTS ; PERSONNEL ; Pigmentation ; PLANTS ; Polychlorinated biphenyls ; Polychlorinated Biphenyls - blood ; Polychlorinated Biphenyls - poisoning ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RICE ; SURVEYS ; SYMPTOMS ; TEXTILE INDUSTRY ; TISSUE DISTRIBUTION ; Toxicity ; Triglycerides ; Workplaces</subject><ispartof>Environ. 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Health Perspect.; (United States)</title><addtitle>Environ Health Perspect</addtitle><description>Surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of thread or of paint, and of Yusho patients were carried out from 1973 to 1982. PCB concentrations in the plasma of the workers ranged from 2 to 521 ppb, and some showed higher PCB levels in the plasma than typical Japanese Yusho patients. Gas chromatographic patterns of plasma PCBs of the workers with high PCB levels were shown to match the patterns of the PCBs to which they had been exposed in the workplace. Japanese Yusho children showed remarkable decrease with time, but no such decrease was observed in the Yusho adults and the workers. Polychlorinated quaterphenyls (PCQs) were detected in the blood of typical Japanese and Taiwanese Yusho patients, but PCQ levels in the plasma of the workers were below the detection limit of 0.02 ppb. Clinical findings and subjective complaints of the workers were usually slight compared with typical Yusho patients, though some of them had mild dermal manifestations and their PCB levels were suspected to be related to serum triglyceride values. On the basis of these results, we discussed the relationship between the health status of the subjects and their contamination with PCBs or related compounds.</description><subject>560306 - Chemicals Metabolism & Toxicology- Man- (-1987)</subject><subject>Adult</subject><subject>AGE DEPENDENCE</subject><subject>AROMATICS</subject><subject>ASIA</subject><subject>BENZOFURANS</subject><subject>Benzofurans - blood</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BLOOD</subject><subject>Blood plasma</subject><subject>BODY FLUIDS</subject><subject>CEREALS</subject><subject>CHEMICAL INDUSTRY</subject><subject>Child</subject><subject>Children</subject><subject>CHLORINATED AROMATIC HYDROCARBONS</subject><subject>Chlorobenzenes - blood</subject><subject>Cholesterols</subject><subject>Dibenzofurans, Polychlorinated</subject><subject>DISTRIBUTION</subject><subject>Food Contamination</subject><subject>FURANS</subject><subject>GRASS</subject><subject>HALOGENATED AROMATIC HYDROCARBONS</subject><subject>HAZARDS</subject><subject>HEALTH HAZARDS</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>Humans</subject><subject>INDUSTRY</subject><subject>JAPAN</subject><subject>MATERIALS</subject><subject>Occupational and Environmental Exposures</subject><subject>OCCUPATIONAL DISEASES</subject><subject>Occupational Diseases - chemically induced</subject><subject>OCCUPATIONAL EXPOSURE</subject><subject>OILS</subject><subject>Oils - poisoning</subject><subject>ORGANIC CHLORINE COMPOUNDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC HALOGEN COMPOUNDS</subject><subject>ORGANIC OXYGEN COMPOUNDS</subject><subject>Oryza - poisoning</subject><subject>OTHER ORGANIC COMPOUNDS</subject><subject>Patient assessment</subject><subject>PATIENTS</subject><subject>PERSONNEL</subject><subject>Pigmentation</subject><subject>PLANTS</subject><subject>Polychlorinated biphenyls</subject><subject>Polychlorinated Biphenyls - blood</subject><subject>Polychlorinated Biphenyls - poisoning</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RICE</subject><subject>SURVEYS</subject><subject>SYMPTOMS</subject><subject>TEXTILE INDUSTRY</subject><subject>TISSUE DISTRIBUTION</subject><subject>Toxicity</subject><subject>Triglycerides</subject><subject>Workplaces</subject><issn>0091-6765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLHEEUhWuh-BiDv0BoRMxqzK2qrkdvBB2MCoKBJISsiprqO05rT9dYt1oy_z4tM4guXF245-OcA4exQw5nQoL5JktRWQtbbA-g4mNttNpl-0SPAMCt1jtsR1aCS8P32PXPPr3gioo4K_7E9ISJivsQ-qXPTex8266Kq3_LSFgXORY_JpdU-K5-pf_2NB8-A4ddpgO2PfMt4ZfNHbHf369-TW7Gd_fXt5OLu3FQ3OSxt1JKrUFUXHMUOFVGlwHFVHE_5XKmARSKUpVaYAjWSC5qb6wvla1t4CBH7Hztu-ynC6zDkJ1865apWfi0ctE37qPSNXP3EF8cV9pCZQeD47VBpNw4Ck3GMA-x6zBkp4QGU8kBOt2kpPjcI2W3aChg2_oOY0-OlxKUgWoAv67BkCJRwtlbEw7udQy3GWMgj94Xf-M2Swz6yVp_pBzTpzb_AW56kBQ</recordid><startdate>19850201</startdate><enddate>19850201</enddate><creator>Takamatsu, Makoto</creator><creator>Oki, Mariko</creator><creator>Maeda, Katsuyoshi</creator><creator>Inoue, Yoshito</creator><creator>Hirayama, Hachiro</creator><creator>Yoshizuka, Keiko</creator><general>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19850201</creationdate><title>Surveys of Workers Occupationally Exposed to PCBs and of Yusho Patients</title><author>Takamatsu, Makoto ; Oki, Mariko ; Maeda, Katsuyoshi ; Inoue, Yoshito ; Hirayama, Hachiro ; Yoshizuka, Keiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-a833366029161e2eb5764ce2b51ab13f6005e245462ecc87312da78a458d8c103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>560306 - Chemicals Metabolism & Toxicology- Man- (-1987)</topic><topic>Adult</topic><topic>AGE DEPENDENCE</topic><topic>AROMATICS</topic><topic>ASIA</topic><topic>BENZOFURANS</topic><topic>Benzofurans - blood</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BLOOD</topic><topic>Blood plasma</topic><topic>BODY FLUIDS</topic><topic>CEREALS</topic><topic>CHEMICAL INDUSTRY</topic><topic>Child</topic><topic>Children</topic><topic>CHLORINATED AROMATIC HYDROCARBONS</topic><topic>Chlorobenzenes - blood</topic><topic>Cholesterols</topic><topic>Dibenzofurans, Polychlorinated</topic><topic>DISTRIBUTION</topic><topic>Food Contamination</topic><topic>FURANS</topic><topic>GRASS</topic><topic>HALOGENATED AROMATIC HYDROCARBONS</topic><topic>HAZARDS</topic><topic>HEALTH HAZARDS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>Humans</topic><topic>INDUSTRY</topic><topic>JAPAN</topic><topic>MATERIALS</topic><topic>Occupational and Environmental Exposures</topic><topic>OCCUPATIONAL DISEASES</topic><topic>Occupational Diseases - chemically induced</topic><topic>OCCUPATIONAL EXPOSURE</topic><topic>OILS</topic><topic>Oils - poisoning</topic><topic>ORGANIC CHLORINE COMPOUNDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC HALOGEN COMPOUNDS</topic><topic>ORGANIC OXYGEN COMPOUNDS</topic><topic>Oryza - poisoning</topic><topic>OTHER ORGANIC COMPOUNDS</topic><topic>Patient assessment</topic><topic>PATIENTS</topic><topic>PERSONNEL</topic><topic>Pigmentation</topic><topic>PLANTS</topic><topic>Polychlorinated biphenyls</topic><topic>Polychlorinated Biphenyls - blood</topic><topic>Polychlorinated Biphenyls - poisoning</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RICE</topic><topic>SURVEYS</topic><topic>SYMPTOMS</topic><topic>TEXTILE INDUSTRY</topic><topic>TISSUE DISTRIBUTION</topic><topic>Toxicity</topic><topic>Triglycerides</topic><topic>Workplaces</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takamatsu, Makoto</creatorcontrib><creatorcontrib>Oki, Mariko</creatorcontrib><creatorcontrib>Maeda, Katsuyoshi</creatorcontrib><creatorcontrib>Inoue, Yoshito</creatorcontrib><creatorcontrib>Hirayama, Hachiro</creatorcontrib><creatorcontrib>Yoshizuka, Keiko</creatorcontrib><creatorcontrib>Kurume Univ., Japan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environ. Health Perspect.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takamatsu, Makoto</au><au>Oki, Mariko</au><au>Maeda, Katsuyoshi</au><au>Inoue, Yoshito</au><au>Hirayama, Hachiro</au><au>Yoshizuka, Keiko</au><aucorp>Kurume Univ., Japan</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surveys of Workers Occupationally Exposed to PCBs and of Yusho Patients</atitle><jtitle>Environ. Health Perspect.; (United States)</jtitle><addtitle>Environ Health Perspect</addtitle><date>1985-02-01</date><risdate>1985</risdate><volume>59</volume><spage>91</spage><epage>97</epage><pages>91-97</pages><issn>0091-6765</issn><abstract>Surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of thread or of paint, and of Yusho patients were carried out from 1973 to 1982. PCB concentrations in the plasma of the workers ranged from 2 to 521 ppb, and some showed higher PCB levels in the plasma than typical Japanese Yusho patients. Gas chromatographic patterns of plasma PCBs of the workers with high PCB levels were shown to match the patterns of the PCBs to which they had been exposed in the workplace. Japanese Yusho children showed remarkable decrease with time, but no such decrease was observed in the Yusho adults and the workers. Polychlorinated quaterphenyls (PCQs) were detected in the blood of typical Japanese and Taiwanese Yusho patients, but PCQ levels in the plasma of the workers were below the detection limit of 0.02 ppb. Clinical findings and subjective complaints of the workers were usually slight compared with typical Yusho patients, though some of them had mild dermal manifestations and their PCB levels were suspected to be related to serum triglyceride values. On the basis of these results, we discussed the relationship between the health status of the subjects and their contamination with PCBs or related compounds.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>3921371</pmid><doi>10.2307/3429880</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 560306 - Chemicals Metabolism & Toxicology- Man- (-1987) Adult AGE DEPENDENCE AROMATICS ASIA BENZOFURANS Benzofurans - blood BIOLOGICAL MATERIALS BLOOD Blood plasma BODY FLUIDS CEREALS CHEMICAL INDUSTRY Child Children CHLORINATED AROMATIC HYDROCARBONS Chlorobenzenes - blood Cholesterols Dibenzofurans, Polychlorinated DISTRIBUTION Food Contamination FURANS GRASS HALOGENATED AROMATIC HYDROCARBONS HAZARDS HEALTH HAZARDS HETEROCYCLIC COMPOUNDS Humans INDUSTRY JAPAN MATERIALS Occupational and Environmental Exposures OCCUPATIONAL DISEASES Occupational Diseases - chemically induced OCCUPATIONAL EXPOSURE OILS Oils - poisoning ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS Oryza - poisoning OTHER ORGANIC COMPOUNDS Patient assessment PATIENTS PERSONNEL Pigmentation PLANTS Polychlorinated biphenyls Polychlorinated Biphenyls - blood Polychlorinated Biphenyls - poisoning RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RICE SURVEYS SYMPTOMS TEXTILE INDUSTRY TISSUE DISTRIBUTION Toxicity Triglycerides Workplaces |
title | Surveys of Workers Occupationally Exposed to PCBs and of Yusho Patients |
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