Surveys of Workers Occupationally Exposed to PCBs and of Yusho Patients

Surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of thread or of paint, and of Yusho patients were carried out from 1973 to 1982. PCB concentrations in the plasma of the workers ranged from 2 to 521 ppb, and some showed higher PCB levels in the plasma t...

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Veröffentlicht in:Environ. Health Perspect.; (United States) 1985-02, Vol.59, p.91-97
Hauptverfasser: Takamatsu, Makoto, Oki, Mariko, Maeda, Katsuyoshi, Inoue, Yoshito, Hirayama, Hachiro, Yoshizuka, Keiko
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container_title Environ. Health Perspect.; (United States)
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creator Takamatsu, Makoto
Oki, Mariko
Maeda, Katsuyoshi
Inoue, Yoshito
Hirayama, Hachiro
Yoshizuka, Keiko
description Surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of thread or of paint, and of Yusho patients were carried out from 1973 to 1982. PCB concentrations in the plasma of the workers ranged from 2 to 521 ppb, and some showed higher PCB levels in the plasma than typical Japanese Yusho patients. Gas chromatographic patterns of plasma PCBs of the workers with high PCB levels were shown to match the patterns of the PCBs to which they had been exposed in the workplace. Japanese Yusho children showed remarkable decrease with time, but no such decrease was observed in the Yusho adults and the workers. Polychlorinated quaterphenyls (PCQs) were detected in the blood of typical Japanese and Taiwanese Yusho patients, but PCQ levels in the plasma of the workers were below the detection limit of 0.02 ppb. Clinical findings and subjective complaints of the workers were usually slight compared with typical Yusho patients, though some of them had mild dermal manifestations and their PCB levels were suspected to be related to serum triglyceride values. On the basis of these results, we discussed the relationship between the health status of the subjects and their contamination with PCBs or related compounds.
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Health Perspect.; (United States)</title><addtitle>Environ Health Perspect</addtitle><description>Surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of thread or of paint, and of Yusho patients were carried out from 1973 to 1982. PCB concentrations in the plasma of the workers ranged from 2 to 521 ppb, and some showed higher PCB levels in the plasma than typical Japanese Yusho patients. Gas chromatographic patterns of plasma PCBs of the workers with high PCB levels were shown to match the patterns of the PCBs to which they had been exposed in the workplace. Japanese Yusho children showed remarkable decrease with time, but no such decrease was observed in the Yusho adults and the workers. Polychlorinated quaterphenyls (PCQs) were detected in the blood of typical Japanese and Taiwanese Yusho patients, but PCQ levels in the plasma of the workers were below the detection limit of 0.02 ppb. 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On the basis of these results, we discussed the relationship between the health status of the subjects and their contamination with PCBs or related compounds.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>3921371</pmid><doi>10.2307/3429880</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects 560306 - Chemicals Metabolism & Toxicology- Man- (-1987)
Adult
AGE DEPENDENCE
AROMATICS
ASIA
BENZOFURANS
Benzofurans - blood
BIOLOGICAL MATERIALS
BLOOD
Blood plasma
BODY FLUIDS
CEREALS
CHEMICAL INDUSTRY
Child
Children
CHLORINATED AROMATIC HYDROCARBONS
Chlorobenzenes - blood
Cholesterols
Dibenzofurans, Polychlorinated
DISTRIBUTION
Food Contamination
FURANS
GRASS
HALOGENATED AROMATIC HYDROCARBONS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
Humans
INDUSTRY
JAPAN
MATERIALS
Occupational and Environmental Exposures
OCCUPATIONAL DISEASES
Occupational Diseases - chemically induced
OCCUPATIONAL EXPOSURE
OILS
Oils - poisoning
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
Oryza - poisoning
OTHER ORGANIC COMPOUNDS
Patient assessment
PATIENTS
PERSONNEL
Pigmentation
PLANTS
Polychlorinated biphenyls
Polychlorinated Biphenyls - blood
Polychlorinated Biphenyls - poisoning
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RICE
SURVEYS
SYMPTOMS
TEXTILE INDUSTRY
TISSUE DISTRIBUTION
Toxicity
Triglycerides
Workplaces
title Surveys of Workers Occupationally Exposed to PCBs and of Yusho Patients
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