Growth-Related Alterations during Liver Carcinogenesis: Effect of Promoters

Bromodeoxyuridine labeling of DNA, binuclearity counting, and flow cytometric analysis of isolated hepatocytes and hepatocyte nuclei has been used to assess hepatocellular growth patterns related to liver carcinogenesis. Three growth patterns can be distinguished. Mononucleating growth is observed d...

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Veröffentlicht in:	Environmental health perspectives 1990-08, Vol.88, p.197-205
Hauptverfasser:	Seglen, Per O., Gerlyng, Per
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Acetylaminofluorene - toxicity 560300 - Chemicals Metabolism & Toxicology ACETYLAMINOFLUORENES ANESTHETICS ANIMAL CELLS Animals ANTICONVULSANTS ANTIMETABOLITES AZINES BARBITURATES BIOLOGICAL EFFECTS BODY BROMOURACILS BUDR CARCINOGENESIS Carcinogens Carcinogens - toxicity Cell Division - drug effects CELL FLOW SYSTEMS Cell growth CELL PROLIFERATION CENTRAL NERVOUS SYSTEM DEPRESSANTS DIGESTIVE SYSTEM Diploidy DNA DRUGS GLANDS Hepatocellular carcinoma Hepatocytes HETEROCYCLIC COMPOUNDS HYDROXY COMPOUNDS HYPNOTICS AND SEDATIVES LIVER LIVER CELLS Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - genetics Liver Neoplasms, Experimental - pathology Multistage Carcinogenesis-Risk Factors and Mechanisms Nodules NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC BROMINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANS PATHOGENESIS PHENOBARBITAL Ploidies PROMOTERS PYRIMIDINES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Rats RIBOSIDES SOMATIC CELLS Tetraploidy TUMOR PROMOTERS Tumors URACILS
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