Quantitative Predictability of Carcinogenicity of the Covalent Binding Index of Chemicals to DNA: Comparison of the In Vivo and In Vitro Assays

The capability of covalent binding to DNA to predict the initiating potential of chemical carcinogens was compared for the assays performed in vivo (rodent liver DNA) and in vitro (purified DNA incubated in the presence of mouse and rat liver microsomes). A quantitative correlation between DNA adduc...

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Veröffentlicht in:	Environmental health perspectives 1990-03, Vol.84, p.183-192
Hauptverfasser:	Taningher, Maurizio, Saccomanno, Giovanna, Santi, Leonardo, Grilli, Sandro, Parodi, Silvio
Format:	Artikel
Sprache:	eng
Schlagworte:	560300 - Chemicals Metabolism & Toxicology ADDUCTS AFLATOXINS ANIMALS ANTIGENS AROMATICS AZAARENES AZOLES BENZENE BENZOPYRENE BIOASSAY BIOLOGICAL RECOVERY BIOLOGICAL REPAIR BODY CARCINOGENESIS Carcinogenicity Carcinogenicity Tests CARCINOGENS Carcinogens - metabolism Carcinogens - toxicity CELL CONSTITUENTS Cell Transformation, Neoplastic - drug effects CELL TRANSFORMATIONS Chemical Phenomena Chemistry, Physical CHLORINATED AROMATIC HYDROCARBONS CHROMOSOMAL ABERRATIONS CONDENSED AROMATICS Correlations DIGESTIVE SYSTEM DNA DNA - metabolism DNA ADDUCTS DNA REPAIR DNA Repair - drug effects EMS ESTERS Genotoxicity GLANDS HALOGENATED AROMATIC HYDROCARBONS Hepatocytes HETEROCYCLIC COMPOUNDS HYDROCARBONS IN VITRO IN VIVO INDOLES LIVER Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - metabolism MAMMALS MATERIALS Metabolism MICE MICROSOMES Microsomes, Liver - drug effects Microsomes, Liver - metabolism MOLECULAR BIOLOGY MUTAGENESIS MUTAGENS MUTATIONS NITROSO COMPOUNDS ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC SULFUR COMPOUNDS ORGANS PATHOGENESIS POLYCYCLIC AROMATIC HYDROCARBONS Predictive Value of Tests PYRROLES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS RECOVERY REPAIR RIBOSOMES RODENTS Sister Chromatid Exchange - drug effects SISTER CHROMATID EXCHANGES SULFONIC ACID ESTERS TOXIC MATERIALS TOXINS VERTEBRATES
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