Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin
A recent study by Rier et al. showed that rhesus monkeys exposed daily for 4 years to 5 or 25 ppt of dioxin in food develop endometriosis, with incidence and severity related to dose. We aimed to determine whether the total time-integrated dioxin exposure of a human population could be comparable to...
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| Veröffentlicht in: | Environmental health perspectives 1994-05, Vol.102 (5), p.476-477 |
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| description | A recent study by Rier et al. showed that rhesus monkeys exposed daily for 4 years to 5 or 25 ppt of dioxin in food develop endometriosis, with incidence and severity related to dose. We aimed to determine whether the total time-integrated dioxin exposure of a human population could be comparable to that of Rier's monkeys. We selected a sample of residents of Seveso, Italy, who were acutely exposed to high levels of dioxin following an accident in 1976. We conducted a toxicokinetic analysis which takes into account species and exposure differences in dose and tming between humans and monkeys. The area under the time-concentration curve for dioxin in fat, which corresponds to cumulative exposure over time, ranges for some of the most heavily exposed Seveso residents from approximately 1.7× 106ppt-days to 1.1× 108ppt-days. These values exceed in all cases the values for the monkeys exposed to 25 ppt or 5 ppt. Given their exposure, the Seveso population should be an ideal epidemiologic cohort to rule out or confirm whether exposure to dioxin leads to an increased risk of endometriosis in humans. |
| doi_str_mv | 10.1289/ehp.94102476 |
| format | Article |
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We aimed to determine whether the total time-integrated dioxin exposure of a human population could be comparable to that of Rier's monkeys. We selected a sample of residents of Seveso, Italy, who were acutely exposed to high levels of dioxin following an accident in 1976. We conducted a toxicokinetic analysis which takes into account species and exposure differences in dose and tming between humans and monkeys. The area under the time-concentration curve for dioxin in fat, which corresponds to cumulative exposure over time, ranges for some of the most heavily exposed Seveso residents from approximately 1.7× 106ppt-days to 1.1× 108ppt-days. These values exceed in all cases the values for the monkeys exposed to 25 ppt or 5 ppt. Given their exposure, the Seveso population should be an ideal epidemiologic cohort to rule out or confirm whether exposure to dioxin leads to an increased risk of endometriosis in humans.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.94102476</identifier><identifier>PMID: 8593852</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Accidents ; Adipose Tissue - metabolism ; ADIPOSE TISSUES ; ALIMENTOS ; Animals ; Blood ; Body fat ; Chemical hazards ; COMPOSE ORGANOCHLORE ; COMPUESTO ORGANICO DEL CLORO ; CONTAMINACION ; CONTAMINATION ; Dioxins ; Dosage ; Endometriosis ; Endometriosis - etiology ; ENFERMEDADES UTERINAS ; Environmental Exposure ; Female ; FEMALES ; FEMELLE ; Food Contamination ; FOODS ; HALOGENATED HYDROCARBONS ; HEMBRA ; HIDROCARBUROS HALOGENADOS ; Humans ; HYDROCARBURE HALOGENE ; INGESTION TOXICITY ; ITALIA ; ITALIE ; ITALY ; KINETICS ; MACACA MULATTA ; MALADIE DE L'UTERUS ; MONKEYS ; MONO ; ORGANOCHLORINE COMPOUNDS ; Polychlorinated Dibenzodioxins - adverse effects ; Polychlorinated Dibenzodioxins - blood ; Polychlorinated Dibenzodioxins - pharmacokinetics ; PRODUIT ALIMENTAIRE ; RIESGO ; RISK ; Risk Factors ; RISQUE ; SINGE ; TEJIDO ADIPOSO ; TISSU ADIPEUX ; TOXICIDAD POR INGESTION ; TOXICITE PAR INGESTION ; TOXICOKINETICS ; UTERINE DISEASES</subject><ispartof>Environmental health perspectives, 1994-05, Vol.102 (5), p.476-477</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3736-70cc5c8607196a6053c0888c51ea2c91060a3be61e3ed75866bf2b2b650c95013</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3432044$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3432044$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,860,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8593852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bois, F.Y</creatorcontrib><creatorcontrib>Eskenazi, B</creatorcontrib><title>Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>A recent study by Rier et al. showed that rhesus monkeys exposed daily for 4 years to 5 or 25 ppt of dioxin in food develop endometriosis, with incidence and severity related to dose. We aimed to determine whether the total time-integrated dioxin exposure of a human population could be comparable to that of Rier's monkeys. We selected a sample of residents of Seveso, Italy, who were acutely exposed to high levels of dioxin following an accident in 1976. We conducted a toxicokinetic analysis which takes into account species and exposure differences in dose and tming between humans and monkeys. The area under the time-concentration curve for dioxin in fat, which corresponds to cumulative exposure over time, ranges for some of the most heavily exposed Seveso residents from approximately 1.7× 106ppt-days to 1.1× 108ppt-days. These values exceed in all cases the values for the monkeys exposed to 25 ppt or 5 ppt. Given their exposure, the Seveso population should be an ideal epidemiologic cohort to rule out or confirm whether exposure to dioxin leads to an increased risk of endometriosis in humans.</description><subject>Accidents</subject><subject>Adipose Tissue - metabolism</subject><subject>ADIPOSE TISSUES</subject><subject>ALIMENTOS</subject><subject>Animals</subject><subject>Blood</subject><subject>Body fat</subject><subject>Chemical hazards</subject><subject>COMPOSE ORGANOCHLORE</subject><subject>COMPUESTO ORGANICO DEL CLORO</subject><subject>CONTAMINACION</subject><subject>CONTAMINATION</subject><subject>Dioxins</subject><subject>Dosage</subject><subject>Endometriosis</subject><subject>Endometriosis - etiology</subject><subject>ENFERMEDADES UTERINAS</subject><subject>Environmental Exposure</subject><subject>Female</subject><subject>FEMALES</subject><subject>FEMELLE</subject><subject>Food Contamination</subject><subject>FOODS</subject><subject>HALOGENATED HYDROCARBONS</subject><subject>HEMBRA</subject><subject>HIDROCARBUROS HALOGENADOS</subject><subject>Humans</subject><subject>HYDROCARBURE HALOGENE</subject><subject>INGESTION TOXICITY</subject><subject>ITALIA</subject><subject>ITALIE</subject><subject>ITALY</subject><subject>KINETICS</subject><subject>MACACA MULATTA</subject><subject>MALADIE DE L'UTERUS</subject><subject>MONKEYS</subject><subject>MONO</subject><subject>ORGANOCHLORINE COMPOUNDS</subject><subject>Polychlorinated Dibenzodioxins - adverse effects</subject><subject>Polychlorinated Dibenzodioxins - blood</subject><subject>Polychlorinated Dibenzodioxins - pharmacokinetics</subject><subject>PRODUIT ALIMENTAIRE</subject><subject>RIESGO</subject><subject>RISK</subject><subject>Risk Factors</subject><subject>RISQUE</subject><subject>SINGE</subject><subject>TEJIDO ADIPOSO</subject><subject>TISSU ADIPEUX</subject><subject>TOXICIDAD POR INGESTION</subject><subject>TOXICITE PAR INGESTION</subject><subject>TOXICOKINETICS</subject><subject>UTERINE DISEASES</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1v1DAQxS0EKkvhxgkJyQfEaVPGduzEHJBQxUelSiCVno3jTFqXJF482ar973HZpSony3o_P7-Zx9hLAUdCtvYdXm6ObC1A1o15xFZCa1lZK-vHbAVgRWUao5-yZ0RXACBaYw7YQautarVcsZ_fE1HsRuQ50i-eBo5znyZcckwUiQ8p8zO8RkprfrL48XbNM1LscV7oPfcz90RINJX738c3m0TbjHxJvI_pJs7P2ZPBj4Qv9uchO__86cfx1-r025eT44-nVVCNMlUDIejQGmiENd6AVgHatg1aoJfBCjDgVYdGoMK-0WWKbpCd7IyGYDUIdcg-7Hw3227CPpRA2Y9uk-Pk861LPrr_lTleuot07YQ2jVCmGLzdG-T0e4u0uClSwHH0M6YtOVErZaTQBVzvwJDL7jIO958IcHeNuNKI-9dIwV8_DHYP7yso-pudfkVLyg-9pILGqVpJqOuCvdphg0_OX5S23PnZ3eQlkfoDYv2bkA</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Bois, F.Y</creator><creator>Eskenazi, B</creator><general>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>5PM</scope></search><sort><creationdate>19940501</creationdate><title>Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin</title><author>Bois, F.Y ; Eskenazi, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3736-70cc5c8607196a6053c0888c51ea2c91060a3be61e3ed75866bf2b2b650c95013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Accidents</topic><topic>Adipose Tissue - metabolism</topic><topic>ADIPOSE TISSUES</topic><topic>ALIMENTOS</topic><topic>Animals</topic><topic>Blood</topic><topic>Body fat</topic><topic>Chemical hazards</topic><topic>COMPOSE ORGANOCHLORE</topic><topic>COMPUESTO ORGANICO DEL CLORO</topic><topic>CONTAMINACION</topic><topic>CONTAMINATION</topic><topic>Dioxins</topic><topic>Dosage</topic><topic>Endometriosis</topic><topic>Endometriosis - etiology</topic><topic>ENFERMEDADES UTERINAS</topic><topic>Environmental Exposure</topic><topic>Female</topic><topic>FEMALES</topic><topic>FEMELLE</topic><topic>Food Contamination</topic><topic>FOODS</topic><topic>HALOGENATED HYDROCARBONS</topic><topic>HEMBRA</topic><topic>HIDROCARBUROS HALOGENADOS</topic><topic>Humans</topic><topic>HYDROCARBURE HALOGENE</topic><topic>INGESTION TOXICITY</topic><topic>ITALIA</topic><topic>ITALIE</topic><topic>ITALY</topic><topic>KINETICS</topic><topic>MACACA MULATTA</topic><topic>MALADIE DE L'UTERUS</topic><topic>MONKEYS</topic><topic>MONO</topic><topic>ORGANOCHLORINE COMPOUNDS</topic><topic>Polychlorinated Dibenzodioxins - adverse effects</topic><topic>Polychlorinated Dibenzodioxins - blood</topic><topic>Polychlorinated Dibenzodioxins - pharmacokinetics</topic><topic>PRODUIT ALIMENTAIRE</topic><topic>RIESGO</topic><topic>RISK</topic><topic>Risk Factors</topic><topic>RISQUE</topic><topic>SINGE</topic><topic>TEJIDO ADIPOSO</topic><topic>TISSU ADIPEUX</topic><topic>TOXICIDAD POR INGESTION</topic><topic>TOXICITE PAR INGESTION</topic><topic>TOXICOKINETICS</topic><topic>UTERINE DISEASES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bois, F.Y</creatorcontrib><creatorcontrib>Eskenazi, B</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bois, F.Y</au><au>Eskenazi, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>102</volume><issue>5</issue><spage>476</spage><epage>477</epage><pages>476-477</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>A recent study by Rier et al. showed that rhesus monkeys exposed daily for 4 years to 5 or 25 ppt of dioxin in food develop endometriosis, with incidence and severity related to dose. We aimed to determine whether the total time-integrated dioxin exposure of a human population could be comparable to that of Rier's monkeys. We selected a sample of residents of Seveso, Italy, who were acutely exposed to high levels of dioxin following an accident in 1976. We conducted a toxicokinetic analysis which takes into account species and exposure differences in dose and tming between humans and monkeys. The area under the time-concentration curve for dioxin in fat, which corresponds to cumulative exposure over time, ranges for some of the most heavily exposed Seveso residents from approximately 1.7× 106ppt-days to 1.1× 108ppt-days. These values exceed in all cases the values for the monkeys exposed to 25 ppt or 5 ppt. Given their exposure, the Seveso population should be an ideal epidemiologic cohort to rule out or confirm whether exposure to dioxin leads to an increased risk of endometriosis in humans.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>8593852</pmid><doi>10.1289/ehp.94102476</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental health perspectives, 1994-05, Vol.102 (5), p.476-477 |
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| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Accidents Adipose Tissue - metabolism ADIPOSE TISSUES ALIMENTOS Animals Blood Body fat Chemical hazards COMPOSE ORGANOCHLORE COMPUESTO ORGANICO DEL CLORO CONTAMINACION CONTAMINATION Dioxins Dosage Endometriosis Endometriosis - etiology ENFERMEDADES UTERINAS Environmental Exposure Female FEMALES FEMELLE Food Contamination FOODS HALOGENATED HYDROCARBONS HEMBRA HIDROCARBUROS HALOGENADOS Humans HYDROCARBURE HALOGENE INGESTION TOXICITY ITALIA ITALIE ITALY KINETICS MACACA MULATTA MALADIE DE L'UTERUS MONKEYS MONO ORGANOCHLORINE COMPOUNDS Polychlorinated Dibenzodioxins - adverse effects Polychlorinated Dibenzodioxins - blood Polychlorinated Dibenzodioxins - pharmacokinetics PRODUIT ALIMENTAIRE RIESGO RISK Risk Factors RISQUE SINGE TEJIDO ADIPOSO TISSU ADIPEUX TOXICIDAD POR INGESTION TOXICITE PAR INGESTION TOXICOKINETICS UTERINE DISEASES |
| title | Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin |
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