Phosphodiesterase IV Inhibitors as Therapy for Eosinophil-Induced Lung Injury in Asthma

Asthma is a complex, multifactorial disease that is underpinned by airway inflammation. A variety of cytotoxic substances are released into the airway from infiltrating inflammatory cells, especially the eosinophil. These cytotoxic substances, including reactive oxygen metabolites, produce damage to...

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Veröffentlicht in:	Environmental health perspectives 1994-12, Vol.102 (suppl 10), p.79-84
Hauptverfasser:	Torphy, Theodore J., Barnette, Mary S., Douglas W. P. Hay, Underwood, David C.
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases Animals Antigens Antigens - immunology Asthma Asthma - drug therapy Asthma - pathology Asthma - physiopathology Bronchoconstriction - drug effects Bronchoconstriction - immunology Cell Adhesion - drug effects Cyclic Nucleotide Phosphodiesterases, Type 4 Cyclic nucleotides Endothelial cells Eosinophils Eosinophils - drug effects Eosinophils - physiology Epithelial cells Epithelium Guinea Pigs Human umbilical vein endothelial cells Lung - pathology Lung injury Male Oxygen Radicals, Inflammation, and Pathogenesis Phosphodiesterase Inhibitors - therapeutic use Phosphoric Diester Hydrolases - metabolism Pyrrolidinones - pharmacology Rolipram Superoxides
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