Impact of Diet on Lead in Blood and Urine in Female Adults and Relevance to Mobilization of Lead from Bone Stores
We measured high precision lead isotope ratios and lead concentrations in blood, urine, and environmental samples to assess the significance of diet as a contributing factor to blood and urine lead levels in a cohort of 23 migrant women and 5 Australian-born women. We evaluated possible correlations...
Gespeichert in:
| Veröffentlicht in: | Environmental health perspectives 1999-04, Vol.107 (4), p.257-263 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 263 |
|---|---|
| container_issue | 4 |
| container_start_page | 257 |
| container_title | Environmental health perspectives |
| container_volume | 107 |
| creator | Gulson, Brian L. Mahaffey, Kathryn R. Jameson, C. William Patison, Nicole Law, Alistair J. Mizon, Karen J. Korsch, Michael J. Pederson, David |
| description | We measured high precision lead isotope ratios and lead concentrations in blood, urine, and environmental samples to assess the significance of diet as a contributing factor to blood and urine lead levels in a cohort of 23 migrant women and 5 Australian-born women. We evaluated possible correlations between levels of dietary lead intake and changes observed in blood and urine lead levels and isotopic composition during pregnancy and postpartum. Mean blood lead concentrations for both groups were approximately 3 μg/dl. The concentration of lead in the diet was 5.8 ± 3 μg Pb/kg [geometric mean (GM) 5.2] and mean daily dietary intake was 8.5 μg/kg/day (GM 7.4), with a range of 2-39 μg/kg/day. Analysis of 6-day duplicate dietary samples for individual subjects commonly showed major spikes in lead concentration and isotopic composition that were not reflected by associated changes in either blood lead concentration or isotopic composition. Changes in blood lead levels and isotopic composition observed during and after pregnancy could not be solely explained by dietary lead. These data are consistent with earlier conclusions that, in cases where levels of environmental lead exposure and dietary lead intake are low, skeletal contribution is the dominant contributor to blood lead, especially during pregnancy and postpartum. |
| doi_str_mv | 10.1289/ehp.99107257 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1566515</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>3434591</jstor_id><sourcerecordid>3434591</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3867-eaaa8c03ad5b0f710459912afd6f9ca1a389a54c015a82beef55cfc1900b1cc63</originalsourceid><addsrcrecordid>eNqFkUFv1DAQRi0EosvCjTPyAfVEiieOnfiC1JYWKi1CaunZmjhj6iqJt3G2Evz6ut22Wk4crJE8T08z8zH2HsQBlI35TFfrA2NA1KWqX7AFKFUWxpTVS7YQwkCha6322JuUroUQ0Gj9mu1B7ohayAW7ORvW6GYePf8aKNeRrwg7HkZ-1MfYcRw7fjmFke6_TmnAnvhht-nn9NA6p55ucXTE58h_xDb04S_OIWuy8cHkpzjwo5gFF3OcKL1lrzz2id491iW7PD35dfy9WP38dnZ8uCqcbHRdECI2TkjsVCt8DaJSecsSfae9cQgoG4OqcgIUNmVL5JVy3oERogXntFyyL1vvetMO1Dka5wl7u57CgNMfGzHYfztjuLK_460FpbUClQX7j4Ip3mwozXYIyVHf40hxkyzUpZbQiP-DlQIp81uyT1vQTTGlifzzNCDsfZg2h2mfwsz4h90NduBtehn4uAWuUz7trqyUoraykvloIO8AsoCmpA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14513351</pqid></control><display><type>article</type><title>Impact of Diet on Lead in Blood and Urine in Female Adults and Relevance to Mobilization of Lead from Bone Stores</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><creator>Gulson, Brian L. ; Mahaffey, Kathryn R. ; Jameson, C. William ; Patison, Nicole ; Law, Alistair J. ; Mizon, Karen J. ; Korsch, Michael J. ; Pederson, David</creator><creatorcontrib>Gulson, Brian L. ; Mahaffey, Kathryn R. ; Jameson, C. William ; Patison, Nicole ; Law, Alistair J. ; Mizon, Karen J. ; Korsch, Michael J. ; Pederson, David</creatorcontrib><description>We measured high precision lead isotope ratios and lead concentrations in blood, urine, and environmental samples to assess the significance of diet as a contributing factor to blood and urine lead levels in a cohort of 23 migrant women and 5 Australian-born women. We evaluated possible correlations between levels of dietary lead intake and changes observed in blood and urine lead levels and isotopic composition during pregnancy and postpartum. Mean blood lead concentrations for both groups were approximately 3 μg/dl. The concentration of lead in the diet was 5.8 ± 3 μg Pb/kg [geometric mean (GM) 5.2] and mean daily dietary intake was 8.5 μg/kg/day (GM 7.4), with a range of 2-39 μg/kg/day. Analysis of 6-day duplicate dietary samples for individual subjects commonly showed major spikes in lead concentration and isotopic composition that were not reflected by associated changes in either blood lead concentration or isotopic composition. Changes in blood lead levels and isotopic composition observed during and after pregnancy could not be solely explained by dietary lead. These data are consistent with earlier conclusions that, in cases where levels of environmental lead exposure and dietary lead intake are low, skeletal contribution is the dominant contributor to blood lead, especially during pregnancy and postpartum.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.99107257</identifier><identifier>PMID: 10090703</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Adult ; Australia - epidemiology ; Blood ; Body Burden ; Bone and Bones - metabolism ; Bones ; Case-Control Studies ; Diet ; Diet - adverse effects ; Diet - statistics & numerical data ; Emigration and Immigration - statistics & numerical data ; Environmental Exposure - analysis ; Environmental Exposure - statistics & numerical data ; Environmental Health ; Female ; Gasoline ; Humans ; Isotopes ; Lead ; Lead - administration & dosage ; Lead - chemistry ; Lead - metabolism ; Lead isotopes ; Least-Squares Analysis ; Linear Models ; Longitudinal Studies ; Maternal Welfare ; Postpartum Period - metabolism ; Pregnancy ; Pregnancy - metabolism ; Time Factors ; Urine ; Women's Health</subject><ispartof>Environmental health perspectives, 1999-04, Vol.107 (4), p.257-263</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3867-eaaa8c03ad5b0f710459912afd6f9ca1a389a54c015a82beef55cfc1900b1cc63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3434591$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3434591$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,864,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10090703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gulson, Brian L.</creatorcontrib><creatorcontrib>Mahaffey, Kathryn R.</creatorcontrib><creatorcontrib>Jameson, C. William</creatorcontrib><creatorcontrib>Patison, Nicole</creatorcontrib><creatorcontrib>Law, Alistair J.</creatorcontrib><creatorcontrib>Mizon, Karen J.</creatorcontrib><creatorcontrib>Korsch, Michael J.</creatorcontrib><creatorcontrib>Pederson, David</creatorcontrib><title>Impact of Diet on Lead in Blood and Urine in Female Adults and Relevance to Mobilization of Lead from Bone Stores</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>We measured high precision lead isotope ratios and lead concentrations in blood, urine, and environmental samples to assess the significance of diet as a contributing factor to blood and urine lead levels in a cohort of 23 migrant women and 5 Australian-born women. We evaluated possible correlations between levels of dietary lead intake and changes observed in blood and urine lead levels and isotopic composition during pregnancy and postpartum. Mean blood lead concentrations for both groups were approximately 3 μg/dl. The concentration of lead in the diet was 5.8 ± 3 μg Pb/kg [geometric mean (GM) 5.2] and mean daily dietary intake was 8.5 μg/kg/day (GM 7.4), with a range of 2-39 μg/kg/day. Analysis of 6-day duplicate dietary samples for individual subjects commonly showed major spikes in lead concentration and isotopic composition that were not reflected by associated changes in either blood lead concentration or isotopic composition. Changes in blood lead levels and isotopic composition observed during and after pregnancy could not be solely explained by dietary lead. These data are consistent with earlier conclusions that, in cases where levels of environmental lead exposure and dietary lead intake are low, skeletal contribution is the dominant contributor to blood lead, especially during pregnancy and postpartum.</description><subject>Adult</subject><subject>Australia - epidemiology</subject><subject>Blood</subject><subject>Body Burden</subject><subject>Bone and Bones - metabolism</subject><subject>Bones</subject><subject>Case-Control Studies</subject><subject>Diet</subject><subject>Diet - adverse effects</subject><subject>Diet - statistics & numerical data</subject><subject>Emigration and Immigration - statistics & numerical data</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Exposure - statistics & numerical data</subject><subject>Environmental Health</subject><subject>Female</subject><subject>Gasoline</subject><subject>Humans</subject><subject>Isotopes</subject><subject>Lead</subject><subject>Lead - administration & dosage</subject><subject>Lead - chemistry</subject><subject>Lead - metabolism</subject><subject>Lead isotopes</subject><subject>Least-Squares Analysis</subject><subject>Linear Models</subject><subject>Longitudinal Studies</subject><subject>Maternal Welfare</subject><subject>Postpartum Period - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy - metabolism</subject><subject>Time Factors</subject><subject>Urine</subject><subject>Women's Health</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQRi0EosvCjTPyAfVEiieOnfiC1JYWKi1CaunZmjhj6iqJt3G2Evz6ut22Wk4crJE8T08z8zH2HsQBlI35TFfrA2NA1KWqX7AFKFUWxpTVS7YQwkCha6322JuUroUQ0Gj9mu1B7ohayAW7ORvW6GYePf8aKNeRrwg7HkZ-1MfYcRw7fjmFke6_TmnAnvhht-nn9NA6p55ucXTE58h_xDb04S_OIWuy8cHkpzjwo5gFF3OcKL1lrzz2id491iW7PD35dfy9WP38dnZ8uCqcbHRdECI2TkjsVCt8DaJSecsSfae9cQgoG4OqcgIUNmVL5JVy3oERogXntFyyL1vvetMO1Dka5wl7u57CgNMfGzHYfztjuLK_460FpbUClQX7j4Ip3mwozXYIyVHf40hxkyzUpZbQiP-DlQIp81uyT1vQTTGlifzzNCDsfZg2h2mfwsz4h90NduBtehn4uAWuUz7trqyUoraykvloIO8AsoCmpA</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Gulson, Brian L.</creator><creator>Mahaffey, Kathryn R.</creator><creator>Jameson, C. William</creator><creator>Patison, Nicole</creator><creator>Law, Alistair J.</creator><creator>Mizon, Karen J.</creator><creator>Korsch, Michael J.</creator><creator>Pederson, David</creator><general>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope><scope>5PM</scope></search><sort><creationdate>19990401</creationdate><title>Impact of Diet on Lead in Blood and Urine in Female Adults and Relevance to Mobilization of Lead from Bone Stores</title><author>Gulson, Brian L. ; Mahaffey, Kathryn R. ; Jameson, C. William ; Patison, Nicole ; Law, Alistair J. ; Mizon, Karen J. ; Korsch, Michael J. ; Pederson, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3867-eaaa8c03ad5b0f710459912afd6f9ca1a389a54c015a82beef55cfc1900b1cc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Australia - epidemiology</topic><topic>Blood</topic><topic>Body Burden</topic><topic>Bone and Bones - metabolism</topic><topic>Bones</topic><topic>Case-Control Studies</topic><topic>Diet</topic><topic>Diet - adverse effects</topic><topic>Diet - statistics & numerical data</topic><topic>Emigration and Immigration - statistics & numerical data</topic><topic>Environmental Exposure - analysis</topic><topic>Environmental Exposure - statistics & numerical data</topic><topic>Environmental Health</topic><topic>Female</topic><topic>Gasoline</topic><topic>Humans</topic><topic>Isotopes</topic><topic>Lead</topic><topic>Lead - administration & dosage</topic><topic>Lead - chemistry</topic><topic>Lead - metabolism</topic><topic>Lead isotopes</topic><topic>Least-Squares Analysis</topic><topic>Linear Models</topic><topic>Longitudinal Studies</topic><topic>Maternal Welfare</topic><topic>Postpartum Period - metabolism</topic><topic>Pregnancy</topic><topic>Pregnancy - metabolism</topic><topic>Time Factors</topic><topic>Urine</topic><topic>Women's Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gulson, Brian L.</creatorcontrib><creatorcontrib>Mahaffey, Kathryn R.</creatorcontrib><creatorcontrib>Jameson, C. William</creatorcontrib><creatorcontrib>Patison, Nicole</creatorcontrib><creatorcontrib>Law, Alistair J.</creatorcontrib><creatorcontrib>Mizon, Karen J.</creatorcontrib><creatorcontrib>Korsch, Michael J.</creatorcontrib><creatorcontrib>Pederson, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gulson, Brian L.</au><au>Mahaffey, Kathryn R.</au><au>Jameson, C. William</au><au>Patison, Nicole</au><au>Law, Alistair J.</au><au>Mizon, Karen J.</au><au>Korsch, Michael J.</au><au>Pederson, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Diet on Lead in Blood and Urine in Female Adults and Relevance to Mobilization of Lead from Bone Stores</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>107</volume><issue>4</issue><spage>257</spage><epage>263</epage><pages>257-263</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>We measured high precision lead isotope ratios and lead concentrations in blood, urine, and environmental samples to assess the significance of diet as a contributing factor to blood and urine lead levels in a cohort of 23 migrant women and 5 Australian-born women. We evaluated possible correlations between levels of dietary lead intake and changes observed in blood and urine lead levels and isotopic composition during pregnancy and postpartum. Mean blood lead concentrations for both groups were approximately 3 μg/dl. The concentration of lead in the diet was 5.8 ± 3 μg Pb/kg [geometric mean (GM) 5.2] and mean daily dietary intake was 8.5 μg/kg/day (GM 7.4), with a range of 2-39 μg/kg/day. Analysis of 6-day duplicate dietary samples for individual subjects commonly showed major spikes in lead concentration and isotopic composition that were not reflected by associated changes in either blood lead concentration or isotopic composition. Changes in blood lead levels and isotopic composition observed during and after pregnancy could not be solely explained by dietary lead. These data are consistent with earlier conclusions that, in cases where levels of environmental lead exposure and dietary lead intake are low, skeletal contribution is the dominant contributor to blood lead, especially during pregnancy and postpartum.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>10090703</pmid><doi>10.1289/ehp.99107257</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 1999-04, Vol.107 (4), p.257-263 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1566515 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Adult Australia - epidemiology Blood Body Burden Bone and Bones - metabolism Bones Case-Control Studies Diet Diet - adverse effects Diet - statistics & numerical data Emigration and Immigration - statistics & numerical data Environmental Exposure - analysis Environmental Exposure - statistics & numerical data Environmental Health Female Gasoline Humans Isotopes Lead Lead - administration & dosage Lead - chemistry Lead - metabolism Lead isotopes Least-Squares Analysis Linear Models Longitudinal Studies Maternal Welfare Postpartum Period - metabolism Pregnancy Pregnancy - metabolism Time Factors Urine Women's Health |
| title | Impact of Diet on Lead in Blood and Urine in Female Adults and Relevance to Mobilization of Lead from Bone Stores |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T17%3A56%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Diet%20on%20Lead%20in%20Blood%20and%20Urine%20in%20Female%20Adults%20and%20Relevance%20to%20Mobilization%20of%20Lead%20from%20Bone%20Stores&rft.jtitle=Environmental%20health%20perspectives&rft.au=Gulson,%20Brian%20L.&rft.date=1999-04-01&rft.volume=107&rft.issue=4&rft.spage=257&rft.epage=263&rft.pages=257-263&rft.issn=0091-6765&rft.eissn=1552-9924&rft_id=info:doi/10.1289/ehp.99107257&rft_dat=%3Cjstor_pubme%3E3434591%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14513351&rft_id=info:pmid/10090703&rft_jstor_id=3434591&rfr_iscdi=true |