Characterization of β‐adrenoceptor mediated smooth muscle relaxation and the detection of mRNA for β1‐, β2‐ and β3‐adrenoceptors in rat ileum

Functional and molecular approaches were used to characterize the β‐AR subtypes mediating relaxation of rat ileal smooth muscle. In functional studies, (−)‐isoprenaline relaxation was unchanged by CGP20712A (β1‐AR antagonist) or ICI118551 (β2‐AR antagonist) but shifted by propranolol (pKB=6.69). (±)...

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Veröffentlicht in:	British journal of pharmacology 1999-06, Vol.127 (4), p.949-961
Hauptverfasser:	Roberts, S J, Papaioannou, M, Evans, B A, Summers, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology gastrointestinal smooth muscle Intestine. Mesentery messenger RNA rat ileum relaxation Vertebrates: digestive system β3‐adrenoceptors β‐adrenoceptors
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