Recovery of impaired K+ channels in mesenteric arteries from spontaneously hypertensive rats by prolonged treatment with cholecalciferol

The mechanism responsible for blood pressure reduction in spontaneously hypertensive rats (SHR) after prolonged cholecalciferol treatment was studied. Two‐week treatment of SHR with 0.125 mg cholecalciferol kg−1 body weight per day orally caused significant reductions of systolic blood pressure and...

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Veröffentlicht in:	British journal of pharmacology 1999-06, Vol.127 (3), p.772-778
Hauptverfasser:	Borges, Antonio C R, Feres, Teresa, Vianna, Lucia M, Paiva, Therezinha B
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha‐2 adrenoceptors Animals Antihypertensive agents Antihypertensive Agents - pharmacology Biological and medical sciences Blood Pressure - drug effects Cardiovascular system cholecalciferol Cholecalciferol - pharmacology Endothelium, Vascular - physiology Female Hypertension - drug therapy Hypertension - physiopathology K+ channels Medical sciences membrane potential Membrane Potentials - drug effects mesenteric arteries Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism Mesenteric Arteries - physiopathology Pharmacology. Drug treatments Potassium Channels - physiology Rats Rats, Inbred SHR Rats, Inbred WKY Rats, Wistar SHR
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