Effects of (−)‐tertatolol, (−)‐penbutolol and (±)‐pindolol in combination with paroxetine on presynaptic 5‐HT function: an in vivo microdialysis and electrophysiological study

The antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs) might be enhanced by co‐administration of 5‐HT1A receptor antagonists. Thus, we have recently shown that the selective 5‐HT1A receptor antagonist, WAY 100635, blocks the inhibitory effect of an SSRI on 5‐HT cell firing, a...

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Veröffentlicht in:	British journal of pharmacology 1999-05, Vol.127 (1), p.145-152
Hauptverfasser:	Gartside, S E, Clifford, E M, Cowen, P J, Sharp, T
Format:	Artikel
Sprache:	eng
Schlagworte:	(±)‐pindolol (−)‐penbutolol (−)‐tertatolol 5‐HT cell firing Adrenergic beta-Antagonists - pharmacology Animals antidepressant Antidepressive Agents - pharmacology Biological and medical sciences Catecholaminergic system Drug Synergism Electrophysiology extracellular 5‐HT In Vitro Techniques Male Medical sciences Membrane Potentials Microdialysis Neuropharmacology Neurotransmitters. Neurotransmission. Receptors paroxetine Paroxetine - pharmacology Patch-Clamp Techniques Penbutolol - pharmacology Pharmacology. Drug treatments Pindolol - pharmacology Propanolamines - pharmacology Prosencephalon - drug effects Prosencephalon - metabolism Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Raphe Nuclei - drug effects Raphe Nuclei - metabolism Rats Rats, Sprague-Dawley Receptors, Presynaptic - drug effects Receptors, Presynaptic - physiology Receptors, Serotonin - drug effects Receptors, Serotonin - physiology Selective Serotonin Reuptake Inhibitors - pharmacology Serotonin - physiology SSRI Thiophenes β‐adrenoceptor/5‐HT1A receptor ligands
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