Comparison of the effects of [Phe1Ψ(CH2‐NH)Gly2]Nociceptin (1–13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors

Nociceptin(NC) is the endogenous ligand for the opioid receptor like‐1 receptor (NC‐receptor). [Phe1ΨC(CH2‐NH)Gly2]Nociceptin(1–13)NH2 ([F/G]NC(1–13)NH2) has been reported to antagonize NC actions in peripheral guinea‐pig and mouse tissues. In this study, we investigated the effects of a range of NC...

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Veröffentlicht in:	British journal of pharmacology 1999-05, Vol.127 (1), p.123-130
Hauptverfasser:	Okawa, Hirobumi, Nicol, Beverley, Bigoni, Raffaella, Hirst, Robert A, Calo', Girolamo, Guerrini, Remo, Rowbotham, David J, Smart, Darren, McKnight, Alexander T, Lambert, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals binding Binding, Competitive Biological and medical sciences Cerebral Cortex - drug effects Cerebral Cortex - metabolism CHO Cells Cricetinae cyclic AMP Cyclic AMP - metabolism Electric Stimulation Female glutamate release Glutamic Acid - metabolism Humans In Vitro Techniques Ligands Male Medical sciences Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors nociceptin receptor Nociceptin/orphanin FQ Opioid Peptides - pharmacology Peptide Fragments - pharmacology Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments rat Rats Rats, Wistar Receptors, Opioid - biosynthesis Recombinant Proteins - biosynthesis vas deferens Vas Deferens - drug effects Vas Deferens - metabolism Vas Deferens - physiology
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