Effects of oral propylthiouracil treatment on nitric oxide production in rat aorta

The effects of oral propylthiouracil (PTU) treatment on vascular nitric oxide (NO) production were studied in the rat aorta. Rats were fed a standard low fat diet with or without 0.1% PTU, for 2 or 4 weeks, or for 2 weeks with additional thyroxine injections. Concentration response curves were then...

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Veröffentlicht in:	British journal of pharmacology 1999-05, Vol.127 (1), p.1-8
Hauptverfasser:	Grieve, David J, Fletcher, Sara, Pitsillides, Andrew A, Botham, Kathleen M, Elliott, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antithyroid Agents - pharmacology Aorta, Thoracic - drug effects Aorta, Thoracic - enzymology Aorta, Thoracic - metabolism Biological and medical sciences Catecholaminergic system Diet endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Immunohistochemistry In Vitro Techniques Male Medical sciences Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - metabolism Neuropharmacology Neurotransmitters. Neurotransmission. Receptors nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - biosynthesis Pharmacology. Drug treatments Phenylephrine - pharmacology Propylthiouracil Propylthiouracil - pharmacology Rabbits rat aorta Rats Rats, Wistar Thyroxine - blood Thyroxine - pharmacology Vasoconstrictor Agents - pharmacology
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