Ca2+ signalling by endothelin receptors in rat and human cultured airway smooth muscle cells

The aim of the current study was to characterize the ET receptor subtypes in cultured airway smooth muscle cells derived from rat trachea and human bronchus using radioligand binding techniques and to investigate the coupling of ET receptors to intracellular calcium signalling mechanisms using endot...

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Veröffentlicht in:	British journal of pharmacology 1998-12, Vol.125 (8), p.1768-1778
Hauptverfasser:	Maxwell, M. J., Goldie, R. G., Henry, P. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Air breathing airway smooth muscle cells Animals Binding, Competitive - drug effects Biological and medical sciences Bronchi - cytology Bronchi - drug effects Bronchi - physiology bronchus Caffeine - pharmacology calcium Calcium - metabolism Calcium - physiology Cell Division - drug effects Cell Division - physiology Cells, Cultured Culture Media, Serum-Free - pharmacology cultured cells Dose-Response Relationship, Drug Endothelin Receptor Antagonists endothelin receptors Endothelin-1 - drug effects Endothelin-1 - metabolism Endothelin-1 - pharmacology Endothelin‐1 Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Humans Iodine Radioisotopes Male Muscle, Smooth - cytology Muscle, Smooth - drug effects Muscle, Smooth - metabolism Oligopeptides Peptides, Cyclic - pharmacology Piperidines Radioligand Assay Rats Rats, Wistar Receptor, Endothelin A Receptor, Endothelin B Receptors, Endothelin - drug effects Receptors, Endothelin - metabolism Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Ryanodine - pharmacology Signal Transduction Thapsigargin - pharmacology trachea Vertebrates: respiratory system Viper Venoms - pharmacology
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