Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors

The cannabinoid receptor antagonist SR141716A has been suggested to be an inverse agonist at CB1 receptors in some isolated intact tissues. We found that the basal incorporation of [35S]‐GTPγS in Chinese hamster ovary cells expressing human recombinant CB1 and CB2 receptors was inhibited by SR141716...

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Veröffentlicht in:	British journal of pharmacology 1998-06, Vol.124 (4), p.619-622
Hauptverfasser:	MacLennan, S J, Reynen, P H, Kwan, J, Bonhaus, D W
Format:	Artikel
Sprache:	eng
Schlagworte:	[35S]‐GTPγS Animals Biological and medical sciences Cannabinoids Cannabinoids - metabolism CB1 receptor CB2 receptor CHO Cells Cricetinae Guanosine 5'-O-(3-Thiotriphosphate) - metabolism human recombinant receptors Humans inverse agonism Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Piperidines - pharmacology Pyrazoles - pharmacology Receptors, Cannabinoid Receptors, Drug - agonists Receptors, Drug - metabolism Recombinant Proteins - agonists Recombinant Proteins - metabolism Special Reports SR141716A
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