Effect of sodium rhein on electrically‐evoked and agonist‐induced contractions of the guinea‐pig isolated ileal circular muscle
This study examined the effects of sodium rhein (0.03–30 μM) on the contractions of the isolated circular muscle of guinea‐pig ileum induced by acetylcholine (100 nM), substance P (3 nM) and electrical stimulation (10 Hz for 0.3 s, 100 mA, 0.5 ms pulse duration). The effect of sodium rhein was also...
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| Veröffentlicht in: | British journal of pharmacology 1998-06, Vol.124 (4), p.825-831 |
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| description | This study examined the effects of sodium rhein (0.03–30 μM) on the contractions of the isolated circular muscle of guinea‐pig ileum induced by acetylcholine (100 nM), substance P (3 nM) and electrical stimulation (10 Hz for 0.3 s, 100 mA, 0.5 ms pulse duration). The effect of sodium rhein was also evaluated on the ascending excitatory reflex using a partitioned bath (oral and anal compartments). Ascending excitatory enteric nerve pathways were activated by electrical field stimulation (10 Hz for 2 s, 20 mA, 0.5 pulse duration) in the anal compartment and the resulting contraction of the guinea‐pig intestinal circular muscle in the oral compartment was recorded.
Sodium rhein (0.3, 3 and 30 μM) significantly potentiated (52±11% at 30 μM) acetylcholine‐induced contractions. In the presence of tetrodotoxin (0.6 μM) or ω‐conotoxin GVIA (10 nM) sodium rhein (3 and 30 μM) did not enhance, but significantly reduced (49±10% and 44±8%, respectively, at 30 μM) acetylcholine‐induced contractions.
Sodium rhein (0.3, 3 and 30 μM) significantly increased (65±11% at 30 μM) substance P‐induced contractions. In the presence of tetrodotoxin (0.6 μM), ω‐conotoxin GVIA (10 nM) or atropine (0.1 μM), sodium rhein (3 and 30 μM) significantly reduced (50±10%, 55±8% and 46±10%, respectively, at 30 μM) substance P‐induced contractions.
NG‐nitro‐L‐arginine methyl ester (L‐NAME, 100 μM) abolished the potentiating effect of sodium rhein on acetylcholine and substance P‐induced contractions. At the highest concentration (30 μM), sodium rhein, in presence of L‐NAME, reduced the acetylcholine (30±6%)‐ or substance P (36±6%)‐induced contractions.
Sodium rhein (30 μM) significantly potentiated (29±9%) the electrically‐evoked contractions. L‐NAME (100 μM), but not phentolamine, enhanced the effect of sodium rhein. Sodium rhein (30 μM) significantly increased (32±9%) the ascending excitatory reflex when applied in the oral, but not in the anal compartment.
These results indicate that sodium rhein (i) activates excitatory cholinergic nerves on circular smooth muscle presumably through a facilitation of Ca2+ entry through the N‐type Ca2+ channel, (ii) has a direct inhibitory effect on circular smooth muscle and (iii) does not affect enteric ascending neuroneural transmission. Nitric oxide could have a modulatory excitatory role on sodium rhein‐induced changes of agonist‐induced contractions and an inhibitory modulator role on sodium rhein‐induced changes of electrically‐induced contractions. |
| doi_str_mv | 10.1038/sj.bjp.0701900 |
| format | Article |
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Sodium rhein (0.3, 3 and 30 μM) significantly potentiated (52±11% at 30 μM) acetylcholine‐induced contractions. In the presence of tetrodotoxin (0.6 μM) or ω‐conotoxin GVIA (10 nM) sodium rhein (3 and 30 μM) did not enhance, but significantly reduced (49±10% and 44±8%, respectively, at 30 μM) acetylcholine‐induced contractions.
Sodium rhein (0.3, 3 and 30 μM) significantly increased (65±11% at 30 μM) substance P‐induced contractions. In the presence of tetrodotoxin (0.6 μM), ω‐conotoxin GVIA (10 nM) or atropine (0.1 μM), sodium rhein (3 and 30 μM) significantly reduced (50±10%, 55±8% and 46±10%, respectively, at 30 μM) substance P‐induced contractions.
NG‐nitro‐L‐arginine methyl ester (L‐NAME, 100 μM) abolished the potentiating effect of sodium rhein on acetylcholine and substance P‐induced contractions. At the highest concentration (30 μM), sodium rhein, in presence of L‐NAME, reduced the acetylcholine (30±6%)‐ or substance P (36±6%)‐induced contractions.
Sodium rhein (30 μM) significantly potentiated (29±9%) the electrically‐evoked contractions. L‐NAME (100 μM), but not phentolamine, enhanced the effect of sodium rhein. Sodium rhein (30 μM) significantly increased (32±9%) the ascending excitatory reflex when applied in the oral, but not in the anal compartment.
These results indicate that sodium rhein (i) activates excitatory cholinergic nerves on circular smooth muscle presumably through a facilitation of Ca2+ entry through the N‐type Ca2+ channel, (ii) has a direct inhibitory effect on circular smooth muscle and (iii) does not affect enteric ascending neuroneural transmission. Nitric oxide could have a modulatory excitatory role on sodium rhein‐induced changes of agonist‐induced contractions and an inhibitory modulator role on sodium rhein‐induced changes of electrically‐induced contractions.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1038/sj.bjp.0701900</identifier><identifier>PMID: 9690877</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetylcholine - pharmacology ; Animals ; Anthraquinone ; Anthraquinones - pharmacology ; Biological and medical sciences ; cholinergic nerves ; Digestive system ; Electric Stimulation ; enteric nervous system ; Guinea Pigs ; Ileum - drug effects ; Ileum - innervation ; Ileum - physiology ; In Vitro Techniques ; intestinal motility ; laxative ; Male ; Medical sciences ; Muscle ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Muscle, Smooth - innervation ; Muscle, Smooth - physiology ; nitric oxide ; Pharmacology. Drug treatments ; Reflex - physiology ; rhein ; senna ; Substance P - pharmacology ; Synaptic Transmission - physiology</subject><ispartof>British journal of pharmacology, 1998-06, Vol.124 (4), p.825-831</ispartof><rights>1998 British Pharmacological Society</rights><rights>1998 INIST-CNRS</rights><rights>Copyright 1998, Nature Publishing Group 1998 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4892-2f3c22fdc8e27538380882f465d08ed00694c94a6f3b5fcf1cc28ad239b323c43</citedby><cites>FETCH-LOGICAL-c4892-2f3c22fdc8e27538380882f465d08ed00694c94a6f3b5fcf1cc28ad239b323c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1565453/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1565453/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27903,27904,45553,45554,46387,46811,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2334907$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9690877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Izzo, Angelo A</creatorcontrib><creatorcontrib>Mascolo, Nicola</creatorcontrib><creatorcontrib>Capasso, Francesco</creatorcontrib><title>Effect of sodium rhein on electrically‐evoked and agonist‐induced contractions of the guinea‐pig isolated ileal circular muscle</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>This study examined the effects of sodium rhein (0.03–30 μM) on the contractions of the isolated circular muscle of guinea‐pig ileum induced by acetylcholine (100 nM), substance P (3 nM) and electrical stimulation (10 Hz for 0.3 s, 100 mA, 0.5 ms pulse duration). The effect of sodium rhein was also evaluated on the ascending excitatory reflex using a partitioned bath (oral and anal compartments). Ascending excitatory enteric nerve pathways were activated by electrical field stimulation (10 Hz for 2 s, 20 mA, 0.5 pulse duration) in the anal compartment and the resulting contraction of the guinea‐pig intestinal circular muscle in the oral compartment was recorded.
Sodium rhein (0.3, 3 and 30 μM) significantly potentiated (52±11% at 30 μM) acetylcholine‐induced contractions. In the presence of tetrodotoxin (0.6 μM) or ω‐conotoxin GVIA (10 nM) sodium rhein (3 and 30 μM) did not enhance, but significantly reduced (49±10% and 44±8%, respectively, at 30 μM) acetylcholine‐induced contractions.
Sodium rhein (0.3, 3 and 30 μM) significantly increased (65±11% at 30 μM) substance P‐induced contractions. In the presence of tetrodotoxin (0.6 μM), ω‐conotoxin GVIA (10 nM) or atropine (0.1 μM), sodium rhein (3 and 30 μM) significantly reduced (50±10%, 55±8% and 46±10%, respectively, at 30 μM) substance P‐induced contractions.
NG‐nitro‐L‐arginine methyl ester (L‐NAME, 100 μM) abolished the potentiating effect of sodium rhein on acetylcholine and substance P‐induced contractions. At the highest concentration (30 μM), sodium rhein, in presence of L‐NAME, reduced the acetylcholine (30±6%)‐ or substance P (36±6%)‐induced contractions.
Sodium rhein (30 μM) significantly potentiated (29±9%) the electrically‐evoked contractions. L‐NAME (100 μM), but not phentolamine, enhanced the effect of sodium rhein. Sodium rhein (30 μM) significantly increased (32±9%) the ascending excitatory reflex when applied in the oral, but not in the anal compartment.
These results indicate that sodium rhein (i) activates excitatory cholinergic nerves on circular smooth muscle presumably through a facilitation of Ca2+ entry through the N‐type Ca2+ channel, (ii) has a direct inhibitory effect on circular smooth muscle and (iii) does not affect enteric ascending neuroneural transmission. Nitric oxide could have a modulatory excitatory role on sodium rhein‐induced changes of agonist‐induced contractions and an inhibitory modulator role on sodium rhein‐induced changes of electrically‐induced contractions.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Anthraquinone</subject><subject>Anthraquinones - pharmacology</subject><subject>Biological and medical sciences</subject><subject>cholinergic nerves</subject><subject>Digestive system</subject><subject>Electric Stimulation</subject><subject>enteric nervous system</subject><subject>Guinea Pigs</subject><subject>Ileum - drug effects</subject><subject>Ileum - innervation</subject><subject>Ileum - physiology</subject><subject>In Vitro Techniques</subject><subject>intestinal motility</subject><subject>laxative</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - innervation</subject><subject>Muscle, Smooth - physiology</subject><subject>nitric oxide</subject><subject>Pharmacology. Drug treatments</subject><subject>Reflex - physiology</subject><subject>rhein</subject><subject>senna</subject><subject>Substance P - pharmacology</subject><subject>Synaptic Transmission - physiology</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTGP1DAQhS0EOpaDlg7JBaLLMrbjxGmQ4HRwSCdBAbXldexdL4692Mmh7Wjo-Y38EhxttILqipGled88z-gh9JzAmgATr_N-vdkf1tAC6QAeoBWp26biTJCHaAUAbUWIEI_Rk5z3AEVs-QW66JoORNuu0K9ra40ecbQ4x95NA0474wKOARtfhOS08v745-dvcxe_mR6rUGobg8tjabrQT7p0dQxjUnp0MeTZa9wZvJ1cMKpAB7fFLkevxkI6b5TH2iU9eZXwMGXtzVP0yCqfzbPlvURf319_ubqpbj99-Hj19rbStehoRS3TlNpeC0PbciITIAS1dcN7EKYHaLpad7VqLNtwqy3RmgrVU9ZtGGW6Zpfozcn3MG0G02szb-3lIblBpaOMysn_leB2chvvJOENrzkrBq8WgxS_TyaPcnBZG-9VMHHKUgDULaHNvSBpOGfAZnB9AnWKOSdjz9sQkHPCMu9lSVguCZeBF__ecMaXSIv-ctFVLtnZpIJ2-YxRxuoOZoydsB8lkeM9n8p3n2-4aCj7C2Ifxds</recordid><startdate>199806</startdate><enddate>199806</enddate><creator>Izzo, Angelo A</creator><creator>Mascolo, Nicola</creator><creator>Capasso, Francesco</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199806</creationdate><title>Effect of sodium rhein on electrically‐evoked and agonist‐induced contractions of the guinea‐pig isolated ileal circular muscle</title><author>Izzo, Angelo A ; Mascolo, Nicola ; Capasso, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4892-2f3c22fdc8e27538380882f465d08ed00694c94a6f3b5fcf1cc28ad239b323c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Anthraquinone</topic><topic>Anthraquinones - pharmacology</topic><topic>Biological and medical sciences</topic><topic>cholinergic nerves</topic><topic>Digestive system</topic><topic>Electric Stimulation</topic><topic>enteric nervous system</topic><topic>Guinea Pigs</topic><topic>Ileum - drug effects</topic><topic>Ileum - innervation</topic><topic>Ileum - physiology</topic><topic>In Vitro Techniques</topic><topic>intestinal motility</topic><topic>laxative</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - innervation</topic><topic>Muscle, Smooth - physiology</topic><topic>nitric oxide</topic><topic>Pharmacology. Drug treatments</topic><topic>Reflex - physiology</topic><topic>rhein</topic><topic>senna</topic><topic>Substance P - pharmacology</topic><topic>Synaptic Transmission - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Izzo, Angelo A</creatorcontrib><creatorcontrib>Mascolo, Nicola</creatorcontrib><creatorcontrib>Capasso, Francesco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Izzo, Angelo A</au><au>Mascolo, Nicola</au><au>Capasso, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of sodium rhein on electrically‐evoked and agonist‐induced contractions of the guinea‐pig isolated ileal circular muscle</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1998-06</date><risdate>1998</risdate><volume>124</volume><issue>4</issue><spage>825</spage><epage>831</epage><pages>825-831</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>This study examined the effects of sodium rhein (0.03–30 μM) on the contractions of the isolated circular muscle of guinea‐pig ileum induced by acetylcholine (100 nM), substance P (3 nM) and electrical stimulation (10 Hz for 0.3 s, 100 mA, 0.5 ms pulse duration). The effect of sodium rhein was also evaluated on the ascending excitatory reflex using a partitioned bath (oral and anal compartments). Ascending excitatory enteric nerve pathways were activated by electrical field stimulation (10 Hz for 2 s, 20 mA, 0.5 pulse duration) in the anal compartment and the resulting contraction of the guinea‐pig intestinal circular muscle in the oral compartment was recorded.
Sodium rhein (0.3, 3 and 30 μM) significantly potentiated (52±11% at 30 μM) acetylcholine‐induced contractions. In the presence of tetrodotoxin (0.6 μM) or ω‐conotoxin GVIA (10 nM) sodium rhein (3 and 30 μM) did not enhance, but significantly reduced (49±10% and 44±8%, respectively, at 30 μM) acetylcholine‐induced contractions.
Sodium rhein (0.3, 3 and 30 μM) significantly increased (65±11% at 30 μM) substance P‐induced contractions. In the presence of tetrodotoxin (0.6 μM), ω‐conotoxin GVIA (10 nM) or atropine (0.1 μM), sodium rhein (3 and 30 μM) significantly reduced (50±10%, 55±8% and 46±10%, respectively, at 30 μM) substance P‐induced contractions.
NG‐nitro‐L‐arginine methyl ester (L‐NAME, 100 μM) abolished the potentiating effect of sodium rhein on acetylcholine and substance P‐induced contractions. At the highest concentration (30 μM), sodium rhein, in presence of L‐NAME, reduced the acetylcholine (30±6%)‐ or substance P (36±6%)‐induced contractions.
Sodium rhein (30 μM) significantly potentiated (29±9%) the electrically‐evoked contractions. L‐NAME (100 μM), but not phentolamine, enhanced the effect of sodium rhein. Sodium rhein (30 μM) significantly increased (32±9%) the ascending excitatory reflex when applied in the oral, but not in the anal compartment.
These results indicate that sodium rhein (i) activates excitatory cholinergic nerves on circular smooth muscle presumably through a facilitation of Ca2+ entry through the N‐type Ca2+ channel, (ii) has a direct inhibitory effect on circular smooth muscle and (iii) does not affect enteric ascending neuroneural transmission. Nitric oxide could have a modulatory excitatory role on sodium rhein‐induced changes of agonist‐induced contractions and an inhibitory modulator role on sodium rhein‐induced changes of electrically‐induced contractions.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9690877</pmid><doi>10.1038/sj.bjp.0701900</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetylcholine - pharmacology Animals Anthraquinone Anthraquinones - pharmacology Biological and medical sciences cholinergic nerves Digestive system Electric Stimulation enteric nervous system Guinea Pigs Ileum - drug effects Ileum - innervation Ileum - physiology In Vitro Techniques intestinal motility laxative Male Medical sciences Muscle Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - innervation Muscle, Smooth - physiology nitric oxide Pharmacology. Drug treatments Reflex - physiology rhein senna Substance P - pharmacology Synaptic Transmission - physiology |
| title | Effect of sodium rhein on electrically‐evoked and agonist‐induced contractions of the guinea‐pig isolated ileal circular muscle |
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