Inhibition of NMDA‐gated ion channels by the P2 purinoceptor antagonists suramin and reactive blue 2 in mouse hippocampal neurones

The action of suramin and reactive blue 2 on N‐methyl‐D‐aspartate (NMDA)‐activated ion current was studied in mouse hippocampal neurones in culture by use of whole‐cell patch‐clamp recording. Suramin and reactive blue 2 inhibited steady‐state current activated by 25 μM NMDA with IC50 values of 68 an...

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Veröffentlicht in:	British journal of pharmacology 1998-05, Vol.124 (2), p.400-408
Hauptverfasser:	Peoples, Robert W, Li, Chaoying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Excitatory Amino Acid Agonists - pharmacology Glutamatergic system (aspartate and other excitatory aminoacids) glycine Glycine - pharmacology hippocampus Hippocampus - drug effects Hippocampus - embryology Hippocampus - metabolism Ion Channels - antagonists & inhibitors Medical sciences Mice N-Methylaspartate - pharmacology Neurons, Afferent - drug effects Neurons, Afferent - metabolism Neuropharmacology Neurotransmitters. Neurotransmission. Receptors NMDA Patch-Clamp Techniques Pharmacology. Drug treatments Protein Synthesis Inhibitors - pharmacology Purinergic P2 Receptor Antagonists purinoceptor Pyridoxal Phosphate - analogs & derivatives Pyridoxal Phosphate - pharmacology reactive blue 2 suramin Suramin - pharmacology Triazines - pharmacology
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