Modulation of extracellular GABA levels in the retina by activation of glial P2X‐purinoceptors

In the rat retina, γ‐aminobutyric acid (GABA) released as a transmitter is inactivated by uptake mainly into glial cells (Müller cells). Activation of P2‐purinoceptors in Müller cells increases [Ca2+]i and the present study was undertaken to see whether this action affected the glial release of [3H]...

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Veröffentlicht in:	British journal of pharmacology 1998-05, Vol.124 (2), p.317-322
Hauptverfasser:	Neal, M J, Cunningham, J R, Dent, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - pharmacology Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Adenosinic and purinergic receptors Animals ATP Biological and medical sciences Cell receptors Cell structures and functions Female Fundamental and applied biological sciences. Psychology GABA release GABA uptake Gabaergic and benzodiazepinic system gamma-Aminobutyric Acid - metabolism Glia Male Medical sciences Molecular and cellular biology Müller cells Neuroglia - metabolism Neuropeptides - metabolism Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Platelet Aggregation Inhibitors - pharmacology Potassium Chloride Purinergic P2 Receptor Agonists Purinergic P2 Receptor Antagonists Pyridoxal Phosphate - analogs & derivatives Pyridoxal Phosphate - pharmacology Rana temporaria Rats Rats, Wistar Receptors, Purinergic P2X2 retina Retina - drug effects Retina - metabolism Thionucleotides - pharmacology
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