Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action

The class III antiarrhythmic azimilide has previously been shown to inhibit IKs and IKr in guinea‐pig cardiac myocytes and IKs (minK) channels expressed in Xenopus oocytes. Because HERG channels underly the conductance IKr in human heart, the effects of azimilide on HERG channels expressed in Xenopu...

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Veröffentlicht in:	British journal of pharmacology 1998-01, Vol.123 (1), p.23-30
Hauptverfasser:	Busch, A E, Eigenberger, B, Jurkiewicz, N K, Salata, J J, Pica, A, Suessbrich, H, Lang, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - pharmacology Antiarythmic agents arrhythmia Azimilide Biological and medical sciences Cardiovascular system Cation Transport Proteins Cell Line DNA-Binding Proteins Electric Stimulation ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels Guinea Pigs HERG Hydantoins IKr IKs Imidazoles - pharmacology Imidazolidines IsK (minK) K+ channel KvLQT1 Medical sciences Membrane Potentials - physiology Oocytes - drug effects Oocytes - metabolism Patch-Clamp Techniques Pharmacology. Drug treatments Piperazines - pharmacology Potassium - pharmacology Potassium Channel Blockers Potassium Channels - metabolism Potassium Channels, Voltage-Gated RNA, Messenger - biosynthesis torsades de pointes Trans-Activators Xenopus
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