Down‐regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver

Infection and inflammation trigger a cascade of mediators that eventually will down‐regulate the hepatic cytochrome P450 (P450). The present study aimed to characterize the mediators contained in the serum of rabbits with an acute inflammatory reaction (AIR) induced by the s.c. injection of turpenti...

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Veröffentlicht in:	British journal of pharmacology 1997-07, Vol.121 (6), p.1164-1170
Hauptverfasser:	El‐Kadi, Ayman O S, Maurice, Hélène, Ong, Huy, Souich, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotransformation Cells, Cultured Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Down-Regulation Fundamental and applied biological sciences. Psychology human serum mediators Humans Inflammation Inflammation Mediators - blood Inflammation Mediators - metabolism Lipid Peroxidation Liver - enzymology Male Molecular and cellular biology rabbit serum mediators Rabbits Theophylline - pharmacokinetics turpentine viral infection Virus Diseases - metabolism
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