The effect of R 15.7/HO, an anti‐CD18 antibody, on the late airway response and airway hyperresponsiveness in an allergic rabbit model

The effects of a mouse (IgG1 fraction) anti‐CD 18 neutralizing antibody (R15.7) on allergen‐induced late airway response (LAR), airway hyperresponsiveness (AHR) and cellular recruitment were investigated in an allergic rabbit model. Litter‐matched NZW rabbits immunized within 24 h of birth with Alte...

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Veröffentlicht in:	British journal of pharmacology 1997-06, Vol.121 (4), p.671-678
Hauptverfasser:	El‐Hashim, A. Z., Jacques, C. A., Herd, C. M., Lee, T. H., Page, C. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	airway hyperresponsiveness Alternaria - immunology Alternaria - metabolism Animals Antibodies, Monoclonal - pharmacology Anti‐CD18, antibody Asthma - immunology Asthma - physiopathology Biological and medical sciences Bronchoalveolar Lavage CD18 Antigens - immunology CD18 Antigens - metabolism Disease Models, Animal Histamine - pharmacology Immunomodulators Inflammation Medical sciences Pharmacology. Drug treatments Rabbits Respiratory Hypersensitivity - immunology
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