The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations

This study was undertaken to investigate the relationship between a reduction in brain GABAA receptor function and the cerebro‐cortical content of 3α‐hydroxy‐5α‐pregnan‐20 one (allopregnanolone, AP), a potent endogenous positive modulator of γ‐aminobutyric acid (GABA) action at GABAA receptors, with...

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Veröffentlicht in:	British journal of pharmacology 1997-04, Vol.120 (8), p.1582-1588
Hauptverfasser:	Barbaccia, M. L., Roscetti, G., Trabucchi, M., Purdy, R. H., Mostallino, M. C., Concas, A., Biggio, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	abecarnil Adrenalectomy allopregnanolone Animals Biological and medical sciences Carbolines - pharmacology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - drug effects Cerebral Cortex - metabolism Corticosterone - blood FG 7142 Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology GABAergic transmission gamma-Aminobutyric Acid - metabolism hypothalamic‐pituitary‐adrenal (HPA) axis isoniazid Isoniazid - pharmacology Male neurosteroids Orchiectomy Pregnanolone - blood Pregnanolone - metabolism Rats Rats, Sprague-Dawley stress Stress, Physiological - metabolism Vertebrates: nervous system and sense organs
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