Pathogenesis of Persistent Hyperplastic Primary Vitreous in Mice Lacking the Arf Tumor Suppressor Gene

Persistent hyperplastic primary vitreous (PHPV) is an idiopathic developmental eye disease associated with failed involution of the hyaloid vasculature. The present work addressed the pathogenesis of PHPV in a mouse model that replicates many aspects of the human disease. Ophthalmoscopic and histolo...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2004-10, Vol.45 (10), p.3387-3396
Hauptverfasser:	Martin, Amy C, Thornton, J. Derek, Liu, Jiewiu, Wang, XiaoFei, Zuo, Jian, Jablonski, Monica M, Chaum, Edward, Zindy, Frederique, Skapek, Stephen X
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Eye Abnormalities - etiology Eye Abnormalities - metabolism Eye Abnormalities - pathology Gene Deletion Gene Expression Regulation Genotype Green Fluorescent Proteins Hyperplasia Immunohistochemistry In Situ Hybridization Luminescent Proteins Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Neovascularization, Pathologic - etiology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Ophthalmology Ophthalmoscopy Retinopathies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Tumor Suppressor Protein p14ARF - genetics Tumor Suppressor Protein p14ARF - metabolism Vitreous Body - abnormalities Vitreous Body - blood supply Vitreous Body - pathology
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