Dynamics of HIV Neutralization by a Microbicide Formulation Layer: Biophysical Fundamentals and Transport Theory

Topical microbicides are an emerging HIV/AIDS prevention modality. Microbicide biofunctionality requires creation of a chemical-physical barrier against HIV transmission. Barrier effectiveness derives from properties of the active compound and its delivery system, but little is known about how these...

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Veröffentlicht in:	Biophysical journal 2006-09, Vol.91 (6), p.2121-2130
Hauptverfasser:	Geonnotti, Anthony R., Katz, David F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravaginal Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacokinetics Bacterial Proteins - pharmacology Biological Transport Biophysical Theory and Modeling Biophysics Carrier Proteins - pharmacology Disease prevention Disease transmission HIV HIV - metabolism HIV Envelope Protein gp120 - metabolism HIV Infections - prevention & control HIV Infections - transmission Human immunodeficiency virus Humans Models, Biological Risk factors Vaginal Creams, Foams, and Jellies Virus Inactivation
Online-Zugang:	Volltext
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