Generation of cross-reactive cytotoxic T lymphocytes following immunization of mice with various bluetongue virus types

Mice immunized with a single bluetongue (BT) virus type were shown to produce cytotoxic T lymphocytes (CTL's) which cross-reactive with a number of BT virus types. These cross-reactive CTL's could be induced by both primary in vivo and secondary in vitro stimulation. A varying degree of cr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunology 1982-04, Vol.45 (4), p.629-636
Hauptverfasser:	Jeggo, M H, Wardley, R C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - biosynthesis Binding, Competitive Bluetongue - immunology bluetongue virus Bluetongue virus - classification Bluetongue virus - immunology Cross Reactions Cytotoxicity, Immunologic Immunization Immunization, Secondary Immunologic Memory Mice Mice, Inbred C3H Neutralization Tests Sheep T-Lymphocytes - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	636
container_issue	4
container_start_page	629
container_title	Immunology
container_volume	45
creator	Jeggo, M H Wardley, R C
description	Mice immunized with a single bluetongue (BT) virus type were shown to produce cytotoxic T lymphocytes (CTL's) which cross-reactive with a number of BT virus types. These cross-reactive CTL's could be induced by both primary in vivo and secondary in vitro stimulation. A varying degree of cross-reactivity occurred with the six BT types examined. Aspects of the character of this cross-reactivity were examined and its role in protection from disease and vaccination strategy is discussed.
format	Article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1555404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15531967</sourcerecordid><originalsourceid>FETCH-LOGICAL-p207t-99cb25ba71175a5ab9e7168611f554b2355b358d9d844a5bed2001207f8259ac3</originalsourceid><addsrcrecordid>eNqFkVFLwzAQx4soc04_gpAn3wpN2jTNiyBDpzDwZT6XJL1ukbSpSdo5P70Bx9Ann477393vf8edJXOclzQltGTnyTzLME9JldHL5Mr795jmGaWzZFYSxouqmif7FfTgRNC2R7ZFylnvUwdCBT0BUodgg_3UCm2QOXTDzkYFPGqtMXav-y3SXTf2-usE6LQCtNdhhybhtB09kmaEYPvtCGjSLgrhMIC_Ti5aYTzcHOMieXt63Cyf0_Xr6mX5sE4HkrGQcq4koVIwjBkVVEgODJdViXFLaSFJTqnMadXwpioKQSU0JB4ZR9uKUC5Uvkjuf7jDKDtoFPTBCVMPTnfCHWordP230utdvbVTjWk0yIoIuDsCnP0YwYe6016BMaKHeF7NimiY8f8bIzDHvGSx8fb3Sqddjj_JvwHHWI0f</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15531967</pqid></control><display><type>article</type><title>Generation of cross-reactive cytotoxic T lymphocytes following immunization of mice with various bluetongue virus types</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Jeggo, M H ; Wardley, R C</creator><creatorcontrib>Jeggo, M H ; Wardley, R C</creatorcontrib><description>Mice immunized with a single bluetongue (BT) virus type were shown to produce cytotoxic T lymphocytes (CTL's) which cross-reactive with a number of BT virus types. These cross-reactive CTL's could be induced by both primary in vivo and secondary in vitro stimulation. A varying degree of cross-reactivity occurred with the six BT types examined. Aspects of the character of this cross-reactivity were examined and its role in protection from disease and vaccination strategy is discussed.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>PMID: 6279488</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Antibodies, Viral - biosynthesis ; Binding, Competitive ; Bluetongue - immunology ; bluetongue virus ; Bluetongue virus - classification ; Bluetongue virus - immunology ; Cross Reactions ; Cytotoxicity, Immunologic ; Immunization ; Immunization, Secondary ; Immunologic Memory ; Mice ; Mice, Inbred C3H ; Neutralization Tests ; Sheep ; T-Lymphocytes - immunology</subject><ispartof>Immunology, 1982-04, Vol.45 (4), p.629-636</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1555404/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1555404/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6279488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeggo, M H</creatorcontrib><creatorcontrib>Wardley, R C</creatorcontrib><title>Generation of cross-reactive cytotoxic T lymphocytes following immunization of mice with various bluetongue virus types</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Mice immunized with a single bluetongue (BT) virus type were shown to produce cytotoxic T lymphocytes (CTL's) which cross-reactive with a number of BT virus types. These cross-reactive CTL's could be induced by both primary in vivo and secondary in vitro stimulation. A varying degree of cross-reactivity occurred with the six BT types examined. Aspects of the character of this cross-reactivity were examined and its role in protection from disease and vaccination strategy is discussed.</description><subject>Animals</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Binding, Competitive</subject><subject>Bluetongue - immunology</subject><subject>bluetongue virus</subject><subject>Bluetongue virus - classification</subject><subject>Bluetongue virus - immunology</subject><subject>Cross Reactions</subject><subject>Cytotoxicity, Immunologic</subject><subject>Immunization</subject><subject>Immunization, Secondary</subject><subject>Immunologic Memory</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Neutralization Tests</subject><subject>Sheep</subject><subject>T-Lymphocytes - immunology</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFLwzAQx4soc04_gpAn3wpN2jTNiyBDpzDwZT6XJL1ukbSpSdo5P70Bx9Ann477393vf8edJXOclzQltGTnyTzLME9JldHL5Mr795jmGaWzZFYSxouqmif7FfTgRNC2R7ZFylnvUwdCBT0BUodgg_3UCm2QOXTDzkYFPGqtMXav-y3SXTf2-usE6LQCtNdhhybhtB09kmaEYPvtCGjSLgrhMIC_Ti5aYTzcHOMieXt63Cyf0_Xr6mX5sE4HkrGQcq4koVIwjBkVVEgODJdViXFLaSFJTqnMadXwpioKQSU0JB4ZR9uKUC5Uvkjuf7jDKDtoFPTBCVMPTnfCHWordP230utdvbVTjWk0yIoIuDsCnP0YwYe6016BMaKHeF7NimiY8f8bIzDHvGSx8fb3Sqddjj_JvwHHWI0f</recordid><startdate>19820401</startdate><enddate>19820401</enddate><creator>Jeggo, M H</creator><creator>Wardley, R C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19820401</creationdate><title>Generation of cross-reactive cytotoxic T lymphocytes following immunization of mice with various bluetongue virus types</title><author>Jeggo, M H ; Wardley, R C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-99cb25ba71175a5ab9e7168611f554b2355b358d9d844a5bed2001207f8259ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>Binding, Competitive</topic><topic>Bluetongue - immunology</topic><topic>bluetongue virus</topic><topic>Bluetongue virus - classification</topic><topic>Bluetongue virus - immunology</topic><topic>Cross Reactions</topic><topic>Cytotoxicity, Immunologic</topic><topic>Immunization</topic><topic>Immunization, Secondary</topic><topic>Immunologic Memory</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Neutralization Tests</topic><topic>Sheep</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeggo, M H</creatorcontrib><creatorcontrib>Wardley, R C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeggo, M H</au><au>Wardley, R C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Generation of cross-reactive cytotoxic T lymphocytes following immunization of mice with various bluetongue virus types</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>1982-04-01</date><risdate>1982</risdate><volume>45</volume><issue>4</issue><spage>629</spage><epage>636</epage><pages>629-636</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Mice immunized with a single bluetongue (BT) virus type were shown to produce cytotoxic T lymphocytes (CTL's) which cross-reactive with a number of BT virus types. These cross-reactive CTL's could be induced by both primary in vivo and secondary in vitro stimulation. A varying degree of cross-reactivity occurred with the six BT types examined. Aspects of the character of this cross-reactivity were examined and its role in protection from disease and vaccination strategy is discussed.</abstract><cop>England</cop><pmid>6279488</pmid><tpages>8</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0019-2805
ispartof	Immunology, 1982-04, Vol.45 (4), p.629-636
issn	0019-2805 1365-2567
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1555404
source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects	Animals Antibodies, Viral - biosynthesis Binding, Competitive Bluetongue - immunology bluetongue virus Bluetongue virus - classification Bluetongue virus - immunology Cross Reactions Cytotoxicity, Immunologic Immunization Immunization, Secondary Immunologic Memory Mice Mice, Inbred C3H Neutralization Tests Sheep T-Lymphocytes - immunology
title	Generation of cross-reactive cytotoxic T lymphocytes following immunization of mice with various bluetongue virus types
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T16%3A09%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Generation%20of%20cross-reactive%20cytotoxic%20T%20lymphocytes%20following%20immunization%20of%20mice%20with%20various%20bluetongue%20virus%20types&rft.jtitle=Immunology&rft.au=Jeggo,%20M%20H&rft.date=1982-04-01&rft.volume=45&rft.issue=4&rft.spage=629&rft.epage=636&rft.pages=629-636&rft.issn=0019-2805&rft.eissn=1365-2567&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E15531967%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15531967&rft_id=info:pmid/6279488&rfr_iscdi=true