Lymphocytotoxic antibodies in patients with systemic lupus erythematosus

Lymphocytotoxic activity could be demonstrated in the sera of patients with systemic lupus erythematosus. The number of positive reactions varied with temperature of incubation. Lymphocytotoxicity was present in 88%, 49% and 11% of sera tested at 15°C, 22°C and 37°C respectively. At an incubation te...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical and experimental immunology 1974-06, Vol.17 (2), p.237-243
Hauptverfasser:	Ooi, B S, Orlina, A R, Pesce, A J, Mendoza, N, Masaitis, L, Pollak, V E
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoantibodies - analysis Cytotoxicity Tests, Immunologic DNA, Single-Stranded - immunology Female Glomerulonephritis - pathology Humans Kidney - pathology Lupus Erythematosus, Systemic - immunology Lymphocytes - immunology Male Nucleoproteins - immunology Temperature
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Lymphocytotoxic activity could be demonstrated in the sera of patients with systemic lupus erythematosus. The number of positive reactions varied with temperature of incubation. Lymphocytotoxicity was present in 88%, 49% and 11% of sera tested at 15°C, 22°C and 37°C respectively. At an incubation temperature of 22°C, the presence of the lymphocytotoxic antibody in the sera could be correlated with significantly higher titres of anti-nuclear factor, anti-single-stranded DNA and the histological appearance of active diffuse glomerulonephritis in renal biopsies.
ISSN:	0009-9104 1365-2249