Platelet aggregation and cryo-IgM in the study of hepatitis and immune complex states
Hepatitis and other sera were studied for direct platelet aggregating (P1.A.) activity in non-heated and heat-treated state, for inhibitability of P1.A. by antiglobulin active cryoglobulin IgM components (Cryo-IgM), and for sedimentation velocity of P1.A. activity by sucrose gradient centrifugation....
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| Veröffentlicht in: | Clinical and experimental immunology 1973-11, Vol.15 (3), p.409-416 |
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| container_title | Clinical and experimental immunology |
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| creator | Penttinen, K Wager, O Räsänen, J A Myllylä, G Haapanen, E |
| description | Hepatitis and other sera were studied for direct platelet aggregating (P1.A.) activity in non-heated and heat-treated state, for inhibitability of P1.A. by antiglobulin active cryoglobulin IgM components (Cryo-IgM), and for sedimentation velocity of P1.A. activity by sucrose gradient centrifugation. Three distinct patterns of direct P1.A. activity were established: (1) `aggregated IgG type': heating-dependent, [unk]19S, inhibitable by Cryo-IgM, serum anticomplementary; (2) `antibody type': heating-independent, 7S and/or 19S, non-inhibitable by Cryo-IgM, serum not anticomplementary; and (3) `immune-complex type': heating-independent, [unk]19S, inhibitable by Cryo-IgM, anticomplementary activity present or absent. In the heavy P1.A.-active sucrose gradient serum fractions of one patient, only IgG4 Gm markers were detected. |
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Three distinct patterns of direct P1.A. activity were established: (1) `aggregated IgG type': heating-dependent, [unk]19S, inhibitable by Cryo-IgM, serum anticomplementary; (2) `antibody type': heating-independent, 7S and/or 19S, non-inhibitable by Cryo-IgM, serum not anticomplementary; and (3) `immune-complex type': heating-independent, [unk]19S, inhibitable by Cryo-IgM, anticomplementary activity present or absent. In the heavy P1.A.-active sucrose gradient serum fractions of one patient, only IgG4 Gm markers were detected.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>PMID: 4271773</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Antigen-Antibody Complex ; Centrifugation, Density Gradient ; Cryoglobulins ; Female ; Glomerulonephritis - immunology ; Hepatitis - immunology ; Hot Temperature ; Humans ; Immune Complex Diseases - immunology ; Immunodiffusion ; Immunoglobulin G - analysis ; Immunoglobulin M ; Liver Cirrhosis, Biliary - immunology ; Lupus Erythematosus, Systemic - immunology ; Male ; Middle Aged ; Myasthenia Gravis - immunology ; Platelet Adhesiveness</subject><ispartof>Clinical and experimental immunology, 1973-11, Vol.15 (3), p.409-416</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1553893/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1553893/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4271773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Penttinen, K</creatorcontrib><creatorcontrib>Wager, O</creatorcontrib><creatorcontrib>Räsänen, J A</creatorcontrib><creatorcontrib>Myllylä, G</creatorcontrib><creatorcontrib>Haapanen, E</creatorcontrib><title>Platelet aggregation and cryo-IgM in the study of hepatitis and immune complex states</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>Hepatitis and other sera were studied for direct platelet aggregating (P1.A.) activity in non-heated and heat-treated state, for inhibitability of P1.A. by antiglobulin active cryoglobulin IgM components (Cryo-IgM), and for sedimentation velocity of P1.A. activity by sucrose gradient centrifugation. Three distinct patterns of direct P1.A. activity were established: (1) `aggregated IgG type': heating-dependent, [unk]19S, inhibitable by Cryo-IgM, serum anticomplementary; (2) `antibody type': heating-independent, 7S and/or 19S, non-inhibitable by Cryo-IgM, serum not anticomplementary; and (3) `immune-complex type': heating-independent, [unk]19S, inhibitable by Cryo-IgM, anticomplementary activity present or absent. In the heavy P1.A.-active sucrose gradient serum fractions of one patient, only IgG4 Gm markers were detected.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigen-Antibody Complex</subject><subject>Centrifugation, Density Gradient</subject><subject>Cryoglobulins</subject><subject>Female</subject><subject>Glomerulonephritis - immunology</subject><subject>Hepatitis - immunology</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Immune Complex Diseases - immunology</subject><subject>Immunodiffusion</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M</subject><subject>Liver Cirrhosis, Biliary - immunology</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myasthenia Gravis - immunology</subject><subject>Platelet Adhesiveness</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF1LwzAUhoMoc05_gpAr7wr5aNLmRpChbjDRC3cd0vSsi7RJbVJx_96iQ_Tq5XAenhfeEzSnXIqMsVydojkhRGWKkvwcXcT4Np1SSjZDs5wVtCj4HG1fWpOghYRN0wzQmOSCx8bX2A6HkK2bJ-w8TnvAMY31AYcd3kM_UcnFb8x13egB29D1LXxO1KSLl-hsZ9oIV8dcoO3D_etylW2eH9fLu03WM0lTxkGaKjeqUhUhhSwLQWpbWyuqnJe8IlLsoM4lqUBSMAXjhBfcKhDApbVK8gW6_fH2Y9VBbcGnwbS6H1xnhoMOxun_H-_2ugkfmgrBS8Unwc1RMIT3EWLSnYsW2tZ4CGPUJaOMC8Um8Ppv02_FcUj-BTI4cg4</recordid><startdate>19731101</startdate><enddate>19731101</enddate><creator>Penttinen, K</creator><creator>Wager, O</creator><creator>Räsänen, J A</creator><creator>Myllylä, G</creator><creator>Haapanen, E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19731101</creationdate><title>Platelet aggregation and cryo-IgM in the study of hepatitis and immune complex states</title><author>Penttinen, K ; Wager, O ; Räsänen, J A ; Myllylä, G ; Haapanen, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p261t-3e6ab4a9b9b00768750dcdcc5b4383b065fed460be61ea7230373c9e5e36cc963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigen-Antibody Complex</topic><topic>Centrifugation, Density Gradient</topic><topic>Cryoglobulins</topic><topic>Female</topic><topic>Glomerulonephritis - immunology</topic><topic>Hepatitis - immunology</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Immune Complex Diseases - immunology</topic><topic>Immunodiffusion</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M</topic><topic>Liver Cirrhosis, Biliary - immunology</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myasthenia Gravis - immunology</topic><topic>Platelet Adhesiveness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Penttinen, K</creatorcontrib><creatorcontrib>Wager, O</creatorcontrib><creatorcontrib>Räsänen, J A</creatorcontrib><creatorcontrib>Myllylä, G</creatorcontrib><creatorcontrib>Haapanen, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Penttinen, K</au><au>Wager, O</au><au>Räsänen, J A</au><au>Myllylä, G</au><au>Haapanen, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet aggregation and cryo-IgM in the study of hepatitis and immune complex states</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1973-11-01</date><risdate>1973</risdate><volume>15</volume><issue>3</issue><spage>409</spage><epage>416</epage><pages>409-416</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><abstract>Hepatitis and other sera were studied for direct platelet aggregating (P1.A.) activity in non-heated and heat-treated state, for inhibitability of P1.A. by antiglobulin active cryoglobulin IgM components (Cryo-IgM), and for sedimentation velocity of P1.A. activity by sucrose gradient centrifugation. Three distinct patterns of direct P1.A. activity were established: (1) `aggregated IgG type': heating-dependent, [unk]19S, inhibitable by Cryo-IgM, serum anticomplementary; (2) `antibody type': heating-independent, 7S and/or 19S, non-inhibitable by Cryo-IgM, serum not anticomplementary; and (3) `immune-complex type': heating-independent, [unk]19S, inhibitable by Cryo-IgM, anticomplementary activity present or absent. In the heavy P1.A.-active sucrose gradient serum fractions of one patient, only IgG4 Gm markers were detected.</abstract><cop>England</cop><pmid>4271773</pmid><tpages>8</tpages></addata></record> |
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| ispartof | Clinical and experimental immunology, 1973-11, Vol.15 (3), p.409-416 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Antigen-Antibody Complex Centrifugation, Density Gradient Cryoglobulins Female Glomerulonephritis - immunology Hepatitis - immunology Hot Temperature Humans Immune Complex Diseases - immunology Immunodiffusion Immunoglobulin G - analysis Immunoglobulin M Liver Cirrhosis, Biliary - immunology Lupus Erythematosus, Systemic - immunology Male Middle Aged Myasthenia Gravis - immunology Platelet Adhesiveness |
| title | Platelet aggregation and cryo-IgM in the study of hepatitis and immune complex states |
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