Successful treatment of an infant with severe combined immunodeficiency by transplantation of bone marrow cells from an uncle
A 4½-month-old boy suffering from congenital severe combined immunodeficiency was successfully treated by transplantation of bone marrow-derived cells. His parents were cousins in the first degree. The donor was a 32-year-old maternal uncle, who was HL-A genotypically identical with the patient as w...
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| Veröffentlicht in: | Clinical and experimental immunology 1973-01, Vol.13 (1), p.9-20 |
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| creator | Vossen, J M de Koning, J van Bekkum, D W Dicke, K A Eysvoogel, V P Hijmans, W van Loghem, E Rádl, J van Rood, J J van der Waay, D Dooren, L J |
| description | A 4½-month-old boy suffering from congenital severe combined immunodeficiency was successfully treated by transplantation of bone marrow-derived cells. His parents were cousins in the first degree. The donor was a 32-year-old maternal uncle, who was HL-A genotypically identical with the patient as was shown by serological typing and MLC. A stem cell rich fraction of the donor's bone marrow was prepared by albumin gradient centrifugation. The infant showed a full immunological reconstitution without any sign of GVH disease. Remarkably the only allotypic marker of his IgG which was different from the donor allotype remained in the serum after transplantation, and even showed an increase of its level.
The infant was nursed in strict reverse isolation and his unfavourable endogenous microflora of high potential pathogenicity was eliminated by antibiotic decontamination. |
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The infant was nursed in strict reverse isolation and his unfavourable endogenous microflora of high potential pathogenicity was eliminated by antibiotic decontamination.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>PMID: 4587502</identifier><language>eng</language><publisher>England</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Bone Marrow Cells ; Bone Marrow Transplantation ; Centrifugation, Density Gradient ; Feces - microbiology ; Genotype ; Histocompatibility Antigens ; Histocompatibility Testing ; Humans ; Immunoglobulin G - analysis ; Immunologic Deficiency Syndromes - genetics ; Immunologic Deficiency Syndromes - nursing ; Immunologic Deficiency Syndromes - therapy ; Infant ; Isoantigens - analysis ; Lymphocyte Activation ; Male ; Patient Isolators ; Pedigree ; Pharynx - microbiology ; Skin - microbiology ; Tissue Donors ; Transplantation, Homologous</subject><ispartof>Clinical and experimental immunology, 1973-01, Vol.13 (1), p.9-20</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1553761/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1553761/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4587502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vossen, J M</creatorcontrib><creatorcontrib>de Koning, J</creatorcontrib><creatorcontrib>van Bekkum, D W</creatorcontrib><creatorcontrib>Dicke, K A</creatorcontrib><creatorcontrib>Eysvoogel, V P</creatorcontrib><creatorcontrib>Hijmans, W</creatorcontrib><creatorcontrib>van Loghem, E</creatorcontrib><creatorcontrib>Rádl, J</creatorcontrib><creatorcontrib>van Rood, J J</creatorcontrib><creatorcontrib>van der Waay, D</creatorcontrib><creatorcontrib>Dooren, L J</creatorcontrib><title>Successful treatment of an infant with severe combined immunodeficiency by transplantation of bone marrow cells from an uncle</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>A 4½-month-old boy suffering from congenital severe combined immunodeficiency was successfully treated by transplantation of bone marrow-derived cells. His parents were cousins in the first degree. The donor was a 32-year-old maternal uncle, who was HL-A genotypically identical with the patient as was shown by serological typing and MLC. A stem cell rich fraction of the donor's bone marrow was prepared by albumin gradient centrifugation. The infant showed a full immunological reconstitution without any sign of GVH disease. Remarkably the only allotypic marker of his IgG which was different from the donor allotype remained in the serum after transplantation, and even showed an increase of its level.
The infant was nursed in strict reverse isolation and his unfavourable endogenous microflora of high potential pathogenicity was eliminated by antibiotic decontamination.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bone Marrow Cells</subject><subject>Bone Marrow Transplantation</subject><subject>Centrifugation, Density Gradient</subject><subject>Feces - microbiology</subject><subject>Genotype</subject><subject>Histocompatibility Antigens</subject><subject>Histocompatibility Testing</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunologic Deficiency Syndromes - genetics</subject><subject>Immunologic Deficiency Syndromes - nursing</subject><subject>Immunologic Deficiency Syndromes - therapy</subject><subject>Infant</subject><subject>Isoantigens - analysis</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Patient Isolators</subject><subject>Pedigree</subject><subject>Pharynx - microbiology</subject><subject>Skin - microbiology</subject><subject>Tissue Donors</subject><subject>Transplantation, Homologous</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LxDAQhoMo67r6E4ScvBXy0bTNRZDFLxA8qOeSpBM30iRr0-6yB_-7WVxET8Mw8z7zvnOE5pRXomCslMdoTgiRhaSkPEVnKX3ktqoqNkOzUjS1IGyOvl4mYyAlO_V4HECNHsKIo8UqYBesys3WjSucYAMDYBO9dgE67LyfQuzAOuMgmB3Wu6xXIa37rFGji2FP0TEA9moY4hYb6PuE7RD9Hj4F08M5OrGqT3BxqAv0dnf7unwonp7vH5c3T8WaVXQsmFVSmrJrgBopa5Cs4cA6owlUlJWmqbkqtagNSM2VIaLh2ggtpK5JI6nlC3T9w11P2kNncsZB9e16cNnbro3Ktf8nwa3a97hpqRC8rmgGXB0AQ_ycII2td2kfSAWIU2obRnl2RfLi5d9LvycOD-ffKzmCEg</recordid><startdate>197301</startdate><enddate>197301</enddate><creator>Vossen, J M</creator><creator>de Koning, J</creator><creator>van Bekkum, D W</creator><creator>Dicke, K A</creator><creator>Eysvoogel, V P</creator><creator>Hijmans, W</creator><creator>van Loghem, E</creator><creator>Rádl, J</creator><creator>van Rood, J J</creator><creator>van der Waay, D</creator><creator>Dooren, L J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>197301</creationdate><title>Successful treatment of an infant with severe combined immunodeficiency by transplantation of bone marrow cells from an uncle</title><author>Vossen, J M ; de Koning, J ; van Bekkum, D W ; Dicke, K A ; Eysvoogel, V P ; Hijmans, W ; van Loghem, E ; Rádl, J ; van Rood, J J ; van der Waay, D ; Dooren, L J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p261t-2fa99c4d8e1c997e9283e2dcb0e6124c873a4b57ce9b3ac0583bc5b59b70891f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bone Marrow Cells</topic><topic>Bone Marrow Transplantation</topic><topic>Centrifugation, Density Gradient</topic><topic>Feces - microbiology</topic><topic>Genotype</topic><topic>Histocompatibility Antigens</topic><topic>Histocompatibility Testing</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunologic Deficiency Syndromes - genetics</topic><topic>Immunologic Deficiency Syndromes - nursing</topic><topic>Immunologic Deficiency Syndromes - therapy</topic><topic>Infant</topic><topic>Isoantigens - analysis</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Patient Isolators</topic><topic>Pedigree</topic><topic>Pharynx - microbiology</topic><topic>Skin - microbiology</topic><topic>Tissue Donors</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vossen, J M</creatorcontrib><creatorcontrib>de Koning, J</creatorcontrib><creatorcontrib>van Bekkum, D W</creatorcontrib><creatorcontrib>Dicke, K A</creatorcontrib><creatorcontrib>Eysvoogel, V P</creatorcontrib><creatorcontrib>Hijmans, W</creatorcontrib><creatorcontrib>van Loghem, E</creatorcontrib><creatorcontrib>Rádl, J</creatorcontrib><creatorcontrib>van Rood, J J</creatorcontrib><creatorcontrib>van der Waay, D</creatorcontrib><creatorcontrib>Dooren, L J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vossen, J M</au><au>de Koning, J</au><au>van Bekkum, D W</au><au>Dicke, K A</au><au>Eysvoogel, V P</au><au>Hijmans, W</au><au>van Loghem, E</au><au>Rádl, J</au><au>van Rood, J J</au><au>van der Waay, D</au><au>Dooren, L J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of an infant with severe combined immunodeficiency by transplantation of bone marrow cells from an uncle</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1973-01</date><risdate>1973</risdate><volume>13</volume><issue>1</issue><spage>9</spage><epage>20</epage><pages>9-20</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><abstract>A 4½-month-old boy suffering from congenital severe combined immunodeficiency was successfully treated by transplantation of bone marrow-derived cells. His parents were cousins in the first degree. The donor was a 32-year-old maternal uncle, who was HL-A genotypically identical with the patient as was shown by serological typing and MLC. A stem cell rich fraction of the donor's bone marrow was prepared by albumin gradient centrifugation. The infant showed a full immunological reconstitution without any sign of GVH disease. Remarkably the only allotypic marker of his IgG which was different from the donor allotype remained in the serum after transplantation, and even showed an increase of its level.
The infant was nursed in strict reverse isolation and his unfavourable endogenous microflora of high potential pathogenicity was eliminated by antibiotic decontamination.</abstract><cop>England</cop><pmid>4587502</pmid><tpages>12</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - therapeutic use Bone Marrow Cells Bone Marrow Transplantation Centrifugation, Density Gradient Feces - microbiology Genotype Histocompatibility Antigens Histocompatibility Testing Humans Immunoglobulin G - analysis Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - nursing Immunologic Deficiency Syndromes - therapy Infant Isoantigens - analysis Lymphocyte Activation Male Patient Isolators Pedigree Pharynx - microbiology Skin - microbiology Tissue Donors Transplantation, Homologous |
| title | Successful treatment of an infant with severe combined immunodeficiency by transplantation of bone marrow cells from an uncle |
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