Characterization of murine monoclonal antibodies against 60‐kD Ro/SS‐A and La/SS‐B autoantigens

SUMMARY Small cytoplasmic ribonucleoproteins (scRNPs) are important autoantigens in patients with systemic lupus erythematosus and Sjögren's syndrome. MoAbs against these proteins were made by immunization of BALB/c mice with purified human recombinant 60‐kD Ro/SS‐A or 50‐kD La/SS‐B proteins. F...

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Veröffentlicht in:	Clinical and experimental immunology 1995-07, Vol.101 (1), p.45-54
Hauptverfasser:	VELDHOVEN, C. H. A., PRUIJN, G. J. M., MEILOF, J. F., THIJSSEN, J. P. H., KEMP, A. W. C. M., VENROOIJ, W. J., SMEENK, R. J. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, immunoglobulins Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Autoantigens - immunology Autoantigens - metabolism Biological and medical sciences Epitope Mapping - standards Fundamental and applied biological sciences. Psychology Fundamental immunology Humans La/SS‐B Mice Mice, Inbred BALB C Molecular immunology Monoclonal antibodies monoclonal antibody Protein Binding - immunology Recombinant Proteins - immunology Ribonucleoproteins - immunology Ribonucleoproteins - metabolism RNA, Small Cytoplasmic Ro/SS‐A Species Specificity SS-B Antigen
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