Anti‐CD11b/CD18 antibodies reduce inflammation in acute colitis in rats

SUMMARY The influx of monocytes and neutrophils into the inflamed tissue could be an important aspect in the pathogenesis of inflammatory bowel disease (IBD). A membrane protein involved in the monocyte/neutrophil adherence to endothelium is CD11b/CD18 or αMβ2 (complement receptor type 3 = CR3). In...

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Veröffentlicht in:	Clinical and experimental immunology 1995-08, Vol.101 (2), p.351-356
Hauptverfasser:	PALMEN, M.J.H.J., DIJKSTRA, C.D., ENDE, M.B., PEÑA, A.S., REES, E.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease adhesion molecules Animals Antibodies - therapeutic use Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Biological and medical sciences CD11b/CD18 CD18 Antigens - immunology colitis Colitis - chemically induced Colitis - immunology Colitis - therapy Gastroenterology. Liver. Pancreas. Abdomen Granulocytes - cytology Granulocytes - immunology Immunotherapy Macrophage-1 Antigen - immunology Macrophages - cytology Macrophages - immunology Male Medical sciences Other diseases. Semiology Peroxidase - metabolism rat Rats Rats, Wistar Stomach. Duodenum. Small intestine. Colon. Rectum. Anus TNBS
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