Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases

The X‐linked disorder oculocerebrorenal syndrome of Lowe is caused by mutation of the OCRL1 protein, an inositol polyphosphate 5‐phosphatase. OCRL1 is localised to the Golgi apparatus and early endosomes, and can translocate to lamellipodia upon growth factor stimulation. We show here that OCRL1 int...

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Veröffentlicht in:	The EMBO journal 2006-08, Vol.25 (16), p.3750-3761
Hauptverfasser:	Hyvola, Noora, Diao, Aipo, McKenzie, Eddie, Skippen, Alison, Cockcroft, Shamshad, Lowe, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biochemistry Cell Compartmentation Cell Line Cell Membrane - metabolism EMBO20 EMBO24 Endocytosis endosome Endosomes - metabolism Enzyme Activation Genetic disorders Golgi apparatus Golgi Apparatus - physiology Humans Membranes Molecular biology Molecular Sequence Data Mutation OCRL1 phosphoinositide Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Phosphotransferases (Alcohol Group Acceptor) - metabolism Point Mutation Protein Binding Protein Transport Proteins rab rab GTP-Binding Proteins - metabolism rab GTP-Binding Proteins - physiology rab1 GTP-Binding Proteins - metabolism rab5 GTP-Binding Proteins - metabolism
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