Bilateral fractures of femoral neck in patients with moderate renal failure receiving fluoride for spinal osteoporosis
Two patients with moderate renal failure sustained spontaneous bilateral hip fractures during treatment with fluoride, calcium, and vitamin D for osteoporosis. They had been taking sodium fluoride (40-60 mg/day) for 11 and 21 months, respectively. Histological examination of a specimen of the bone s...
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| Veröffentlicht in: | BMJ 1983-09, Vol.287 (6394), p.723-725 |
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| creator | Gerster, J C Charhon, S A Jaeger, P Boivin, G Briancon, D Rostan, A Baud, C A Meunier, P J |
| description | Two patients with moderate renal failure sustained spontaneous bilateral hip fractures during treatment with fluoride, calcium, and vitamin D for osteoporosis. They had been taking sodium fluoride (40-60 mg/day) for 11 and 21 months, respectively. Histological examination of a specimen of the bone showed severe fluorosis in the first case, and quantitative analysis of bone showed osteomalacia and skeletal fluorosis in the other case. These abnormalities were considered to be the consequence of excessive retention of fluoride due to renal insufficiency. As bilateral femoral neck fractures are very rare these data suggest a causal link between fractures and fluoride in patients with renal failure. Thus fluoride should be given at a lower dosage, if at all, to patients with even mild renal failure. |
| doi_str_mv | 10.1136/bmj.287.6394.723 |
| format | Article |
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They had been taking sodium fluoride (40-60 mg/day) for 11 and 21 months, respectively. Histological examination of a specimen of the bone showed severe fluorosis in the first case, and quantitative analysis of bone showed osteomalacia and skeletal fluorosis in the other case. These abnormalities were considered to be the consequence of excessive retention of fluoride due to renal insufficiency. As bilateral femoral neck fractures are very rare these data suggest a causal link between fractures and fluoride in patients with renal failure. Thus fluoride should be given at a lower dosage, if at all, to patients with even mild renal failure.</description><identifier>ISSN: 0007-1447</identifier><identifier>ISSN: 0267-0623</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.287.6394.723</identifier><identifier>PMID: 6311315</identifier><identifier>CODEN: BMJOAE</identifier><language>eng</language><publisher>London: British Medical Journal Publishing Group</publisher><subject>Aged ; Biological and medical sciences ; Bone and Bones - pathology ; Bones ; Calcium ; Calcium - therapeutic use ; Cholecalciferol - therapeutic use ; Drug Therapy, Combination ; Drug toxicity and drugs side effects treatment ; Female ; Femoral Neck Fractures - chemically induced ; Fluoride treatments ; Fluorides ; Fluorosis ; Fractures, Spontaneous - chemically induced ; Hip fractures ; Humans ; Kidney failure ; Kidney Failure, Chronic - complications ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Osteomalacia - pathology ; Osteoporosis ; Osteoporosis - complications ; Osteoporosis - drug therapy ; Pharmacology. Drug treatments ; Sodium ; Sodium Fluoride - adverse effects ; Spinal fractures</subject><ispartof>BMJ, 1983-09, Vol.287 (6394), p.723-725</ispartof><rights>Copyright 1983 British Medical Journal</rights><rights>1984 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Sep 10, 1983</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b575t-5d313f59f1f91f94ba474918c03d5a1ff5e2071d2b9d08c90dd0798309b825023</citedby><cites>FETCH-LOGICAL-b575t-5d313f59f1f91f94ba474918c03d5a1ff5e2071d2b9d08c90dd0798309b825023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29512206$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29512206$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9379622$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6311315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerster, J C</creatorcontrib><creatorcontrib>Charhon, S A</creatorcontrib><creatorcontrib>Jaeger, P</creatorcontrib><creatorcontrib>Boivin, G</creatorcontrib><creatorcontrib>Briancon, D</creatorcontrib><creatorcontrib>Rostan, A</creatorcontrib><creatorcontrib>Baud, C A</creatorcontrib><creatorcontrib>Meunier, P J</creatorcontrib><title>Bilateral fractures of femoral neck in patients with moderate renal failure receiving fluoride for spinal osteoporosis</title><title>BMJ</title><addtitle>Br Med J (Clin Res Ed)</addtitle><description>Two patients with moderate renal failure sustained spontaneous bilateral hip fractures during treatment with fluoride, calcium, and vitamin D for osteoporosis. They had been taking sodium fluoride (40-60 mg/day) for 11 and 21 months, respectively. Histological examination of a specimen of the bone showed severe fluorosis in the first case, and quantitative analysis of bone showed osteomalacia and skeletal fluorosis in the other case. These abnormalities were considered to be the consequence of excessive retention of fluoride due to renal insufficiency. As bilateral femoral neck fractures are very rare these data suggest a causal link between fractures and fluoride in patients with renal failure. Thus fluoride should be given at a lower dosage, if at all, to patients with even mild renal failure.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - pathology</subject><subject>Bones</subject><subject>Calcium</subject><subject>Calcium - therapeutic use</subject><subject>Cholecalciferol - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Femoral Neck Fractures - chemically induced</subject><subject>Fluoride treatments</subject><subject>Fluorides</subject><subject>Fluorosis</subject><subject>Fractures, Spontaneous - chemically induced</subject><subject>Hip fractures</subject><subject>Humans</subject><subject>Kidney failure</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Osteomalacia - pathology</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Osteoporosis - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Sodium</subject><subject>Sodium Fluoride - adverse effects</subject><subject>Spinal fractures</subject><issn>0007-1447</issn><issn>0267-0623</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc2L1DAYxoMo6zDu3YsQULxIx3w2zUVwB3XFRS_qYS8hbZPdzLZNTdpR_3vfMsP4cREKJXl-z8v75EHoMSUbSnn5su53G1apTcm12CjG76EVFWVVyIrz-2hFCFEFFUI9ROc57-DIuKp0Kc7QWclhApUrtL8InZ1csh32yTbTnFzG0WPv-rhcDq65w2HAo52CG6aMv4fpFvexBcvkcHLD4rShAyOcGhf2YbjBvptjCq3DPiacx7BQMU8ujjHFHPIj9MDbLrvz43-Nvrx983l7WVx9evd--_qqqKWSUyFbTrmX2lOv4RO1FUpoWjWEt9JS76VjRNGW1bolVaNJ2xKlK050XTEJedfo1WHuONe9axuIAKnMmEJv008TbTB_K0O4NTdxb6gUmsA7rtHz44AUv80uT6YPuXFdZwcX52wo11RVlQDw6T_gLs4JcgOjVCmIpqUCihyoBp4hJ-dPq1BillINlGqgVLOUaqBUsDz5M8LJcKwQ9GdH3ebGdtDi0IR8wjRXumTs95hdnmI6yUxLyhgpQS8OeoCafpx0m-4M7K2k-fh1a651SbcXHy7NNfAvDvyy8H9D_AJ5z9JV</recordid><startdate>19830910</startdate><enddate>19830910</enddate><creator>Gerster, J C</creator><creator>Charhon, S A</creator><creator>Jaeger, P</creator><creator>Boivin, G</creator><creator>Briancon, D</creator><creator>Rostan, A</creator><creator>Baud, C A</creator><creator>Meunier, P J</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QP</scope><scope>5PM</scope></search><sort><creationdate>19830910</creationdate><title>Bilateral fractures of femoral neck in patients with moderate renal failure receiving fluoride for spinal osteoporosis</title><author>Gerster, J C ; Charhon, S A ; Jaeger, P ; Boivin, G ; Briancon, D ; Rostan, A ; Baud, C A ; Meunier, P J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b575t-5d313f59f1f91f94ba474918c03d5a1ff5e2071d2b9d08c90dd0798309b825023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - pathology</topic><topic>Bones</topic><topic>Calcium</topic><topic>Calcium - therapeutic use</topic><topic>Cholecalciferol - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Femoral Neck Fractures - chemically induced</topic><topic>Fluoride treatments</topic><topic>Fluorides</topic><topic>Fluorosis</topic><topic>Fractures, Spontaneous - chemically induced</topic><topic>Hip fractures</topic><topic>Humans</topic><topic>Kidney failure</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Osteomalacia - pathology</topic><topic>Osteoporosis</topic><topic>Osteoporosis - complications</topic><topic>Osteoporosis - drug therapy</topic><topic>Pharmacology. 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They had been taking sodium fluoride (40-60 mg/day) for 11 and 21 months, respectively. Histological examination of a specimen of the bone showed severe fluorosis in the first case, and quantitative analysis of bone showed osteomalacia and skeletal fluorosis in the other case. These abnormalities were considered to be the consequence of excessive retention of fluoride due to renal insufficiency. As bilateral femoral neck fractures are very rare these data suggest a causal link between fractures and fluoride in patients with renal failure. Thus fluoride should be given at a lower dosage, if at all, to patients with even mild renal failure.</abstract><cop>London</cop><pub>British Medical Journal Publishing Group</pub><pmid>6311315</pmid><doi>10.1136/bmj.287.6394.723</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biological and medical sciences Bone and Bones - pathology Bones Calcium Calcium - therapeutic use Cholecalciferol - therapeutic use Drug Therapy, Combination Drug toxicity and drugs side effects treatment Female Femoral Neck Fractures - chemically induced Fluoride treatments Fluorides Fluorosis Fractures, Spontaneous - chemically induced Hip fractures Humans Kidney failure Kidney Failure, Chronic - complications Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Osteomalacia - pathology Osteoporosis Osteoporosis - complications Osteoporosis - drug therapy Pharmacology. Drug treatments Sodium Sodium Fluoride - adverse effects Spinal fractures |
| title | Bilateral fractures of femoral neck in patients with moderate renal failure receiving fluoride for spinal osteoporosis |
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