Hypocholesterolaemia and non-cardiovascular disease: metabolic studies on subjects with low plasma cholesterol concentrations
Some epidemiological studies have suggested an inverse relation between serum cholesterol concentration and mortality from cancer. Two hypotheses that might explain such a relation were investigated. To assay potentially deleterious effects of hypocholesterolaemia on cell membranes the lipid content...
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| Veröffentlicht in: | BMJ 1983-05, Vol.286 (6378), p.1603-1606 |
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| creator | Marenah, C B Lewis, B Hassall, D La Ville, A Cortese, C Mitchell, W D Bruckdorfer, K R Slavin, B Miller, N E Turner, P R Heduan, E |
| description | Some epidemiological studies have suggested an inverse relation between serum cholesterol concentration and mortality from cancer. Two hypotheses that might explain such a relation were investigated. To assay potentially deleterious effects of hypocholesterolaemia on cell membranes the lipid content and fluidity of blood mononuclear cells were measured in healthy male volunteers with a wide range of serum cholesterol concentration (3.2-10.0 mmol/l (124-387 mg/100 ml)). Fluidity, unesterified cholesterol content, and the ratio of cholesterol to phospholipid were unrelated to serum cholesterol and to low density lipoprotein cholesterol concentrations. Similar measurements were made on fibroblasts and mononuclear cells incubated with a range of concentrations of low density lipoprotein; fluidity was altered only at extremely low concentrations, suggesting that changes in cell membranes are unlikely to occur at serum cholesterol concentrations attainable by dietary or drug treatment of hyperlipidaemia. In the same population direct relations were confirmed between low density lipoprotein concentration and plasma concentrations of retinol and beta carotene. This is compatible with the suggestion that an association between low cholesterol concentration and cancer may be secondary to a relation between low retinoid concentrations and cancer. |
| doi_str_mv | 10.1136/bmj.286.6378.1603 |
| format | Article |
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Two hypotheses that might explain such a relation were investigated. To assay potentially deleterious effects of hypocholesterolaemia on cell membranes the lipid content and fluidity of blood mononuclear cells were measured in healthy male volunteers with a wide range of serum cholesterol concentration (3.2-10.0 mmol/l (124-387 mg/100 ml)). Fluidity, unesterified cholesterol content, and the ratio of cholesterol to phospholipid were unrelated to serum cholesterol and to low density lipoprotein cholesterol concentrations. Similar measurements were made on fibroblasts and mononuclear cells incubated with a range of concentrations of low density lipoprotein; fluidity was altered only at extremely low concentrations, suggesting that changes in cell membranes are unlikely to occur at serum cholesterol concentrations attainable by dietary or drug treatment of hyperlipidaemia. In the same population direct relations were confirmed between low density lipoprotein concentration and plasma concentrations of retinol and beta carotene. This is compatible with the suggestion that an association between low cholesterol concentration and cancer may be secondary to a relation between low retinoid concentrations and cancer.</description><identifier>ISSN: 0007-1447</identifier><identifier>ISSN: 0267-0623</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.286.6378.1603</identifier><identifier>PMID: 6405907</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Adult ; beta Carotene ; Blood plasma ; Carotenoids - blood ; Cell membranes ; Cells, Cultured ; Cholesterol - blood ; Cholesterol - metabolism ; Cholesterol, HDL ; Cholesterol, LDL ; Cholesterol, VLDL ; Cholesterols ; Clinical Research ; Density ; Fibroblasts ; Fibroblasts - metabolism ; hematologic tests ; Humans ; hypocholesterolemia ; Lipoproteins ; Lipoproteins, HDL - blood ; Lipoproteins, LDL - blood ; Lipoproteins, VLDL - blood ; Lymphocytes - metabolism ; Male ; males ; metabolic studies ; Middle Aged ; neoplasms ; Neoplasms - blood ; nutrition research ; Phospholipids ; Phospholipids - metabolism ; Plasma density ; risk factors ; Serum cholesterol ; Teeth ; Viscosity ; Vitamin A - blood</subject><ispartof>BMJ, 1983-05, Vol.286 (6378), p.1603-1606</ispartof><rights>Copyright 1983 British Medical Journal</rights><rights>Copyright BMJ Publishing Group LTD May 21, 1983</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4583-f3c783463543a8d5a0a6e8a3f57803471c72394d1c5a0fbd465759047547f5023</citedby><cites>FETCH-LOGICAL-b4583-f3c783463543a8d5a0a6e8a3f57803471c72394d1c5a0fbd465759047547f5023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29510961$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29510961$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6405907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marenah, C B</creatorcontrib><creatorcontrib>Lewis, B</creatorcontrib><creatorcontrib>Hassall, D</creatorcontrib><creatorcontrib>La Ville, A</creatorcontrib><creatorcontrib>Cortese, C</creatorcontrib><creatorcontrib>Mitchell, W D</creatorcontrib><creatorcontrib>Bruckdorfer, K R</creatorcontrib><creatorcontrib>Slavin, B</creatorcontrib><creatorcontrib>Miller, N E</creatorcontrib><creatorcontrib>Turner, P R</creatorcontrib><creatorcontrib>Heduan, E</creatorcontrib><title>Hypocholesterolaemia and non-cardiovascular disease: metabolic studies on subjects with low plasma cholesterol concentrations</title><title>BMJ</title><addtitle>Br Med J (Clin Res Ed)</addtitle><description>Some epidemiological studies have suggested an inverse relation between serum cholesterol concentration and mortality from cancer. Two hypotheses that might explain such a relation were investigated. To assay potentially deleterious effects of hypocholesterolaemia on cell membranes the lipid content and fluidity of blood mononuclear cells were measured in healthy male volunteers with a wide range of serum cholesterol concentration (3.2-10.0 mmol/l (124-387 mg/100 ml)). Fluidity, unesterified cholesterol content, and the ratio of cholesterol to phospholipid were unrelated to serum cholesterol and to low density lipoprotein cholesterol concentrations. Similar measurements were made on fibroblasts and mononuclear cells incubated with a range of concentrations of low density lipoprotein; fluidity was altered only at extremely low concentrations, suggesting that changes in cell membranes are unlikely to occur at serum cholesterol concentrations attainable by dietary or drug treatment of hyperlipidaemia. In the same population direct relations were confirmed between low density lipoprotein concentration and plasma concentrations of retinol and beta carotene. This is compatible with the suggestion that an association between low cholesterol concentration and cancer may be secondary to a relation between low retinoid concentrations and cancer.</description><subject>Adult</subject><subject>beta Carotene</subject><subject>Blood plasma</subject><subject>Carotenoids - blood</subject><subject>Cell membranes</subject><subject>Cells, Cultured</subject><subject>Cholesterol - blood</subject><subject>Cholesterol - metabolism</subject><subject>Cholesterol, HDL</subject><subject>Cholesterol, LDL</subject><subject>Cholesterol, VLDL</subject><subject>Cholesterols</subject><subject>Clinical Research</subject><subject>Density</subject><subject>Fibroblasts</subject><subject>Fibroblasts - metabolism</subject><subject>hematologic tests</subject><subject>Humans</subject><subject>hypocholesterolemia</subject><subject>Lipoproteins</subject><subject>Lipoproteins, HDL - blood</subject><subject>Lipoproteins, LDL - blood</subject><subject>Lipoproteins, VLDL - blood</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>males</subject><subject>metabolic studies</subject><subject>Middle Aged</subject><subject>neoplasms</subject><subject>Neoplasms - blood</subject><subject>nutrition research</subject><subject>Phospholipids</subject><subject>Phospholipids - metabolism</subject><subject>Plasma density</subject><subject>risk factors</subject><subject>Serum cholesterol</subject><subject>Teeth</subject><subject>Viscosity</subject><subject>Vitamin A - blood</subject><issn>0007-1447</issn><issn>0267-0623</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU9v1DAQxSMEKqvSD8ABYQmJE1ns2LETDkho-VPUAkKlHLhYE8fpOiTxYictPfS7d1ZZLYULJ8t6v3maNy9JHjO6ZIzLl1XfLrNCLiVXxZJJyu8lCyZkkeYF5_eTBaVUpUwI9TA5irHFb4ZkKcVBciAFzUuqFsnN8fXGm7XvbBxt8B3Y3gGBoSaDH1IDoXb-EqKZOgikdtFCtK9Ib0eofOcMieNUOxuJH0icqtaaMZIrN65J56_IpoPYA7ljT4wfjB3GAKPzQ3yUPGigi_Zo9x4m5-_ffVsdp6dfPnxcvTlNK4Fh0oYbVXAheS44FHUOFKQtgDe5KigXihmV8VLUzKDUVLWQucJ4QuVCNTnGPkxez76bqeptPW_Q6U1wPYRr7cHpv5XBrfWFv9QMHfBkaPB8ZxD8rwnD6N5FY7sOBuunqAsqCkalQvDZP2DrpzBgOM2UwrOXZVYixWbKBB9jsM1-FUb1tlyN5WosV2_L1dtycebJ3Qz7iV2Vf_Q2jj7s5azMGS0lQz2ddYdV_N7rEH5q3Fvl-vP3lT75-uOEiU9v9RnyT2e-Aa_hIrioz88yyjjNJJV4biRezMR22f8HuAUvDNJD</recordid><startdate>19830521</startdate><enddate>19830521</enddate><creator>Marenah, C B</creator><creator>Lewis, B</creator><creator>Hassall, D</creator><creator>La Ville, A</creator><creator>Cortese, C</creator><creator>Mitchell, W D</creator><creator>Bruckdorfer, K R</creator><creator>Slavin, B</creator><creator>Miller, N E</creator><creator>Turner, P R</creator><creator>Heduan, E</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19830521</creationdate><title>Hypocholesterolaemia and non-cardiovascular disease: metabolic studies on subjects with low plasma cholesterol concentrations</title><author>Marenah, C B ; Lewis, B ; Hassall, D ; La Ville, A ; Cortese, C ; Mitchell, W D ; Bruckdorfer, K R ; Slavin, B ; Miller, N E ; Turner, P R ; Heduan, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4583-f3c783463543a8d5a0a6e8a3f57803471c72394d1c5a0fbd465759047547f5023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>beta Carotene</topic><topic>Blood plasma</topic><topic>Carotenoids - blood</topic><topic>Cell membranes</topic><topic>Cells, Cultured</topic><topic>Cholesterol - blood</topic><topic>Cholesterol - metabolism</topic><topic>Cholesterol, HDL</topic><topic>Cholesterol, LDL</topic><topic>Cholesterol, VLDL</topic><topic>Cholesterols</topic><topic>Clinical Research</topic><topic>Density</topic><topic>Fibroblasts</topic><topic>Fibroblasts - metabolism</topic><topic>hematologic tests</topic><topic>Humans</topic><topic>hypocholesterolemia</topic><topic>Lipoproteins</topic><topic>Lipoproteins, HDL - blood</topic><topic>Lipoproteins, LDL - blood</topic><topic>Lipoproteins, VLDL - blood</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>males</topic><topic>metabolic studies</topic><topic>Middle Aged</topic><topic>neoplasms</topic><topic>Neoplasms - blood</topic><topic>nutrition research</topic><topic>Phospholipids</topic><topic>Phospholipids - metabolism</topic><topic>Plasma density</topic><topic>risk factors</topic><topic>Serum cholesterol</topic><topic>Teeth</topic><topic>Viscosity</topic><topic>Vitamin A - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marenah, C B</creatorcontrib><creatorcontrib>Lewis, B</creatorcontrib><creatorcontrib>Hassall, D</creatorcontrib><creatorcontrib>La Ville, A</creatorcontrib><creatorcontrib>Cortese, C</creatorcontrib><creatorcontrib>Mitchell, W D</creatorcontrib><creatorcontrib>Bruckdorfer, K R</creatorcontrib><creatorcontrib>Slavin, B</creatorcontrib><creatorcontrib>Miller, N E</creatorcontrib><creatorcontrib>Turner, P R</creatorcontrib><creatorcontrib>Heduan, E</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Research Library</collection><collection>Science Database (ProQuest)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marenah, C B</au><au>Lewis, B</au><au>Hassall, D</au><au>La Ville, A</au><au>Cortese, C</au><au>Mitchell, W D</au><au>Bruckdorfer, K R</au><au>Slavin, B</au><au>Miller, N E</au><au>Turner, P R</au><au>Heduan, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypocholesterolaemia and non-cardiovascular disease: metabolic studies on subjects with low plasma cholesterol concentrations</atitle><jtitle>BMJ</jtitle><addtitle>Br Med J (Clin Res Ed)</addtitle><date>1983-05-21</date><risdate>1983</risdate><volume>286</volume><issue>6378</issue><spage>1603</spage><epage>1606</epage><pages>1603-1606</pages><issn>0007-1447</issn><issn>0267-0623</issn><issn>0959-8138</issn><eissn>1468-5833</eissn><abstract>Some epidemiological studies have suggested an inverse relation between serum cholesterol concentration and mortality from cancer. Two hypotheses that might explain such a relation were investigated. To assay potentially deleterious effects of hypocholesterolaemia on cell membranes the lipid content and fluidity of blood mononuclear cells were measured in healthy male volunteers with a wide range of serum cholesterol concentration (3.2-10.0 mmol/l (124-387 mg/100 ml)). Fluidity, unesterified cholesterol content, and the ratio of cholesterol to phospholipid were unrelated to serum cholesterol and to low density lipoprotein cholesterol concentrations. Similar measurements were made on fibroblasts and mononuclear cells incubated with a range of concentrations of low density lipoprotein; fluidity was altered only at extremely low concentrations, suggesting that changes in cell membranes are unlikely to occur at serum cholesterol concentrations attainable by dietary or drug treatment of hyperlipidaemia. In the same population direct relations were confirmed between low density lipoprotein concentration and plasma concentrations of retinol and beta carotene. This is compatible with the suggestion that an association between low cholesterol concentration and cancer may be secondary to a relation between low retinoid concentrations and cancer.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>6405907</pmid><doi>10.1136/bmj.286.6378.1603</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-1447 |
| ispartof | BMJ, 1983-05, Vol.286 (6378), p.1603-1606 |
| issn | 0007-1447 0267-0623 0959-8138 1468-5833 |
| language | eng |
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| source | MEDLINE; PubMed Central; JSTOR |
| subjects | Adult beta Carotene Blood plasma Carotenoids - blood Cell membranes Cells, Cultured Cholesterol - blood Cholesterol - metabolism Cholesterol, HDL Cholesterol, LDL Cholesterol, VLDL Cholesterols Clinical Research Density Fibroblasts Fibroblasts - metabolism hematologic tests Humans hypocholesterolemia Lipoproteins Lipoproteins, HDL - blood Lipoproteins, LDL - blood Lipoproteins, VLDL - blood Lymphocytes - metabolism Male males metabolic studies Middle Aged neoplasms Neoplasms - blood nutrition research Phospholipids Phospholipids - metabolism Plasma density risk factors Serum cholesterol Teeth Viscosity Vitamin A - blood |
| title | Hypocholesterolaemia and non-cardiovascular disease: metabolic studies on subjects with low plasma cholesterol concentrations |
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