Decreased antihaemophilic globulin and leucocyte response to epinephrine in preterm infants
Twenty-one preterm and 23 term neonates, 13 splenectomized children and one with congenital asplenia, and 20 normal children were examined for plasma antihaemophilic activity and for blood leucocyte levels before and 30 minutes after a subcutaneous injection of epinephrine 0-01 mg/kg. The basal valu...
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| Veröffentlicht in: | Archives of disease in childhood 1976-03, Vol.51 (3), p.231-233 |
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| creator | Spirer, Z Shalit, I Zakuth, V Svirsky-Fein, S Milbauer, B Bogair, N |
| description | Twenty-one preterm and 23 term neonates, 13 splenectomized children and one with congenital asplenia, and 20 normal children were examined for plasma antihaemophilic activity and for blood leucocyte levels before and 30 minutes after a subcutaneous injection of epinephrine 0-01 mg/kg. The basal values for antihaemophilic activity were similar for the 4 groups. The response to epinephrine was a trivial rise in antihaemophilic activity in the preterm group, while the rise in the term newborns was comparable to that of the normal children. The asplenic children all showed a trivial rise. The leucocyte response was also negligible in both the preterm neonates and asplenic groups, while in the term infants it was comparable to that seen in the normal children. These results may indicate an incapacity of the preterm newborn infant's reticuloendothelial system and spleen to react to other challenges, such as bacterial infection. |
| doi_str_mv | 10.1136/adc.51.3.231 |
| format | Article |
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The basal values for antihaemophilic activity were similar for the 4 groups. The response to epinephrine was a trivial rise in antihaemophilic activity in the preterm group, while the rise in the term newborns was comparable to that of the normal children. The asplenic children all showed a trivial rise. The leucocyte response was also negligible in both the preterm neonates and asplenic groups, while in the term infants it was comparable to that seen in the normal children. These results may indicate an incapacity of the preterm newborn infant's reticuloendothelial system and spleen to react to other challenges, such as bacterial infection.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.51.3.231</identifier><identifier>PMID: 952558</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Bacterial diseases ; Child ; Child, Preschool ; Epinephrine - pharmacology ; Factor VIII - analysis ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infants ; Leukocytes - drug effects ; Male ; Mononuclear Phagocyte System - physiology ; Neonates ; Spleen - physiology</subject><ispartof>Archives of disease in childhood, 1976-03, Vol.51 (3), p.231-233</ispartof><rights>Copyright BMJ Publishing Group LTD Mar 1976</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3911-faa379204014e2487878d254c39677f82a4dee1bce6344fbfb9c32f46d4efebc3</citedby><cites>FETCH-LOGICAL-b3911-faa379204014e2487878d254c39677f82a4dee1bce6344fbfb9c32f46d4efebc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1545934/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1545934/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/952558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spirer, Z</creatorcontrib><creatorcontrib>Shalit, I</creatorcontrib><creatorcontrib>Zakuth, V</creatorcontrib><creatorcontrib>Svirsky-Fein, S</creatorcontrib><creatorcontrib>Milbauer, B</creatorcontrib><creatorcontrib>Bogair, N</creatorcontrib><title>Decreased antihaemophilic globulin and leucocyte response to epinephrine in preterm infants</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Twenty-one preterm and 23 term neonates, 13 splenectomized children and one with congenital asplenia, and 20 normal children were examined for plasma antihaemophilic activity and for blood leucocyte levels before and 30 minutes after a subcutaneous injection of epinephrine 0-01 mg/kg. The basal values for antihaemophilic activity were similar for the 4 groups. The response to epinephrine was a trivial rise in antihaemophilic activity in the preterm group, while the rise in the term newborns was comparable to that of the normal children. The asplenic children all showed a trivial rise. The leucocyte response was also negligible in both the preterm neonates and asplenic groups, while in the term infants it was comparable to that seen in the normal children. These results may indicate an incapacity of the preterm newborn infant's reticuloendothelial system and spleen to react to other challenges, such as bacterial infection.</description><subject>Bacterial diseases</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Epinephrine - pharmacology</subject><subject>Factor VIII - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infants</subject><subject>Leukocytes - drug effects</subject><subject>Male</subject><subject>Mononuclear Phagocyte System - physiology</subject><subject>Neonates</subject><subject>Spleen - physiology</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc2L1TAUxYP49RzduXRREHRjn7nNR5PNgD51FAbdjIPgIqTp7bw826YmrTj_vZEOD3UhgZvA-XFyLoeQx0C3AEy-tK3bCtiybcXgFtkAl6qsKOe3yYZSykqtlLpPHqR0oBQqpdg9cleLSgi1IV_foItoE7aFHWe_tziEae9774qrPjRL78cstEWPiwvuesYiYprCmLCYQ4GTH3HaxzyLDE4RZ4xDfnbZLD0kdzrbJ3x0c5-Qz-_eXuzel-efzj7sXp2XDdMAZWctq3UOTIFjxVWdT1sJ7piWdd2pyvIWERqHknHeNV2jHas6LluOHTaOnZDT1XdamgFbh-McbW-m6Acbr02w3vytjH5vrsIPA4ILzXg2eHZjEMP3BdNsBp8c9r0dMSzJKMYrIQVk8Ok_4CEscczLGailrjVIKjP1YqVcDClF7I5RgJrfjZncmBFgmMmNZfzJn_GP8FpRlstV9mnGn0fVxm9G1qwW5uPlznzRr3cAF5fmLPPPV74ZDv__-Bdv0687</recordid><startdate>19760301</startdate><enddate>19760301</enddate><creator>Spirer, Z</creator><creator>Shalit, I</creator><creator>Zakuth, V</creator><creator>Svirsky-Fein, S</creator><creator>Milbauer, B</creator><creator>Bogair, N</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19760301</creationdate><title>Decreased antihaemophilic globulin and leucocyte response to epinephrine in preterm infants</title><author>Spirer, Z ; 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The basal values for antihaemophilic activity were similar for the 4 groups. The response to epinephrine was a trivial rise in antihaemophilic activity in the preterm group, while the rise in the term newborns was comparable to that of the normal children. The asplenic children all showed a trivial rise. The leucocyte response was also negligible in both the preterm neonates and asplenic groups, while in the term infants it was comparable to that seen in the normal children. These results may indicate an incapacity of the preterm newborn infant's reticuloendothelial system and spleen to react to other challenges, such as bacterial infection.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>952558</pmid><doi>10.1136/adc.51.3.231</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of disease in childhood, 1976-03, Vol.51 (3), p.231-233 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Bacterial diseases Child Child, Preschool Epinephrine - pharmacology Factor VIII - analysis Female Humans Infant Infant, Newborn Infant, Premature Infants Leukocytes - drug effects Male Mononuclear Phagocyte System - physiology Neonates Spleen - physiology |
| title | Decreased antihaemophilic globulin and leucocyte response to epinephrine in preterm infants |
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