Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm

Biogenesis of functional spliceosomal small nuclear RNAs (snRNAs) includes the post‐transcriptional covalent modification of numerous internal nucleotides. We have recently demonstrated that synthesis of 2′‐ O ‐methylated nucleotides and pseudouridines in the RNA polymerase II‐synthesized Sm snRNAs...

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