FGFR1 is independently required in both developing mid‐ and hindbrain for sustained response to isthmic signals

Fibroblast growth factors (FGFs) are signaling molecules of the isthmic organizer, which regulates development of the midbrain and cerebellum. Tissue‐specific inactivation of one of the FGF receptor (FGFR) genes, Fgfr1 , in the midbrain and rhombomere 1 of the hindbrain of mouse embryos results in d...

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Veröffentlicht in:	The EMBO journal 2003-04, Vol.22 (8), p.1811-1823
Hauptverfasser:	Trokovic, Ras, Trokovic, Nina, Hernesniemi, Sanna, Pirvola, Ulla, Vogt Weisenhorn, Daniela M., Rossant, Janet, McMahon, Andrew P., Wurst, Wolfgang, Partanen, Juha
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Cadherins - genetics Cadherins - metabolism Cell Adhesion - physiology Cell Survival - physiology cerebellum Cre recombinase development EMBO05 EMBO11 Embryo, Mammalian - anatomy & histology Embryo, Mammalian - physiology Ephrin-A5 - genetics Ephrin-A5 - metabolism FGF Gene Expression Regulation, Developmental Gestational Age Growth factors Homeodomain Proteins - genetics Homeodomain Proteins - metabolism In Situ Hybridization Inactivation Integrases - genetics Integrases - metabolism isthmic organizer Mesencephalon - anatomy & histology Mesencephalon - growth & development Mesencephalon - metabolism Mice Mice, Transgenic midbrain Motor Activity - physiology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptor, Fibroblast Growth Factor, Type 1 Receptor, Fibroblast Growth Factor, Type 2 Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - metabolism Rhombencephalon - anatomy & histology Rhombencephalon - growth & development Rhombencephalon - metabolism Signal Transduction - physiology Viral Proteins - genetics Viral Proteins - metabolism Wnt Proteins Zebrafish Proteins
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