Inhibition of Aldehyde Dehydrogenase and Retinoid Signaling Induces the Expansion of Human Hematopoietic Stem Cells

Aldehyde dehydrogenase (ALDH) is an enzyme that is expressed in the liver and is required for the conversion of retinol (vitamin A) to retinoic acids. ALDH is also highly enriched in hematopoietic stem cells (HSCs) and is considered a selectable marker of human HSCs, although its contribution to ste...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-08, Vol.103 (31), p.11707-11712
Hauptverfasser:	Chute, John P., Muramoto, Garrett G., Whitesides, John, Colvin, Michael, Safi, Rachid, Chao, Nelson J., McDonnell, Donald P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Dehydrogenase - antagonists & inhibitors Aldehyde Dehydrogenase - metabolism Aldehydes Animals Antigens, CD - metabolism B lymphocytes Biological Sciences Cell Differentiation - physiology Cells, Cultured Cellular biology Cellular differentiation Cultured cells Cytokines Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Homeodomain Proteins - metabolism Humans Hydrogenases Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Mice Mice, SCID Myeloid cells p-Aminoazobenzene - analogs & derivatives Progenitor cells Retinal Dehydrogenase Retinoids Retinoids - metabolism Signal Transduction - physiology Stem cell transplantation Stem cells Transcription Factors - metabolism Vitamin A
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