Alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, augments cyclosporin A inhibition of cytolytic T lymphocyte induction

The objective of the present investigation was to examine the effect of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, in combination with the immunosuppressant cyclosporin A (CsA) on cytolytic T lymphocytes (CTL) induction in vitro and in vivo. Treatment...

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Veröffentlicht in:	Clinical and experimental immunology 1989-07, Vol.77 (1), p.151-156
Hauptverfasser:	BOWLIN, T. L, ROSENBERGER, A. L, MCKOWN, B. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylmethionine Decarboxylase - antagonists & inhibitors Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Cells, Cultured Cyclosporins - pharmacology Eflornithine - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Interleukin-2 - biosynthesis Lymphocyte Activation - drug effects Male Mice Mice, Inbred C57BL Mice, Inbred DBA Miscellaneous Ornithine Decarboxylase Inhibitors Polyamines - metabolism Regulatory factors and their cellular receptors T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - metabolism
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