Demonstration in vitro of cell mediated immunity to Epstein-Barr virus in cotton-top tamarins
In the course of developing an effective Epstein-Barr (EB) virus vaccine, the immune responses in cotton-top tamarins to a tumourigenic dose of EB virus were studied. Cell mediated responses were measured using a tissue culture 'growth inhibition' assay where peripheral blood lymphocytes w...
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Veröffentlicht in: | Clinical and experimental immunology 1988-08, Vol.73 (2), p.181-185 |
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description | In the course of developing an effective Epstein-Barr (EB) virus vaccine, the immune responses in cotton-top tamarins to a tumourigenic dose of EB virus were studied. Cell mediated responses were measured using a tissue culture 'growth inhibition' assay where peripheral blood lymphocytes were tested for their ability to inhibit the outgrowth of autologous EB virus transformed lymphoblastoid cells. This system has previously been recognized as a very sensitive assay for detecting cell-mediated responses to EB virus in man. Using this assay no cell-mediated immunity was detected up to the time of death in two tamarins following injection with a tumourigenic dose of EB virus. However, two other animals which had recovered from tumours induced by a first dose of EB virus 18 months previously when subsequently re-stimulated with a second tumourigenic dose did exhibit cell-mediated responses. These latter animals remained healthy following the re-challenge and did not show evidence of EB virus-induced disease. |
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T ; MORGAN, A. J</creator><creatorcontrib>FINERTY, S ; SCULLION, F. T ; MORGAN, A. J</creatorcontrib><description>In the course of developing an effective Epstein-Barr (EB) virus vaccine, the immune responses in cotton-top tamarins to a tumourigenic dose of EB virus were studied. Cell mediated responses were measured using a tissue culture 'growth inhibition' assay where peripheral blood lymphocytes were tested for their ability to inhibit the outgrowth of autologous EB virus transformed lymphoblastoid cells. This system has previously been recognized as a very sensitive assay for detecting cell-mediated responses to EB virus in man. Using this assay no cell-mediated immunity was detected up to the time of death in two tamarins following injection with a tumourigenic dose of EB virus. However, two other animals which had recovered from tumours induced by a first dose of EB virus 18 months previously when subsequently re-stimulated with a second tumourigenic dose did exhibit cell-mediated responses. These latter animals remained healthy following the re-challenge and did not show evidence of EB virus-induced disease.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>PMID: 2846217</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Animals ; Biological and medical sciences ; Callitrichinae - immunology ; Cell Division ; Cell Transformation, Viral ; Cells, Cultured ; Epstein-Barr virus ; Fundamental and applied biological sciences. 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T</creatorcontrib><creatorcontrib>MORGAN, A. J</creatorcontrib><title>Demonstration in vitro of cell mediated immunity to Epstein-Barr virus in cotton-top tamarins</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>In the course of developing an effective Epstein-Barr (EB) virus vaccine, the immune responses in cotton-top tamarins to a tumourigenic dose of EB virus were studied. Cell mediated responses were measured using a tissue culture 'growth inhibition' assay where peripheral blood lymphocytes were tested for their ability to inhibit the outgrowth of autologous EB virus transformed lymphoblastoid cells. This system has previously been recognized as a very sensitive assay for detecting cell-mediated responses to EB virus in man. Using this assay no cell-mediated immunity was detected up to the time of death in two tamarins following injection with a tumourigenic dose of EB virus. However, two other animals which had recovered from tumours induced by a first dose of EB virus 18 months previously when subsequently re-stimulated with a second tumourigenic dose did exhibit cell-mediated responses. These latter animals remained healthy following the re-challenge and did not show evidence of EB virus-induced disease.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Callitrichinae - immunology</subject><subject>Cell Division</subject><subject>Cell Transformation, Viral</subject><subject>Cells, Cultured</subject><subject>Epstein-Barr virus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Herpesvirus 4, Human - immunology</subject><subject>Immunity, Cellular</subject><subject>Immunologic Memory</subject><subject>Microbiology</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Tumor Virus Infections - veterinary</subject><subject>Virology</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMo4zj6E4QsxF2heTbZCDqODxhwo0spaZpqpE1qkgrz783gMOjK1eVyzj185x6AOSKcFRhTeQjmZVnKQqKSHoOTGD_yyjnHMzDDgnKMqjl4vTWDdzEFlax30Dr4ZVPw0HdQm76Hg2mtSqaFdhgmZ9MGJg9XY0zGuuJGhZD9YYrbQ-1T8q5IfoRJDSpYF0_BUaf6aM52cwFe7lbPy4di_XT_uLxeFyMmPBWGdbTpGiWxqIxqCReIE2YqrQXVDSsx4ojQpioJxhobURGKS6aNYg1uW9mSBbj6yR2nJhNr43Khvh6DzRyb2itb_1Wcfa_f_FeNGEVM8hxwuQsI_nMyMdWDjdsHKGf8FOtKUEkFpv8aEStzIGXZeP4bac-y-3zWL3a6ilr1XVBO27i35a5SCEm-Abfwj0Q</recordid><startdate>19880801</startdate><enddate>19880801</enddate><creator>FINERTY, S</creator><creator>SCULLION, F. T</creator><creator>MORGAN, A. J</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19880801</creationdate><title>Demonstration in vitro of cell mediated immunity to Epstein-Barr virus in cotton-top tamarins</title><author>FINERTY, S ; SCULLION, F. T ; MORGAN, A. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p236t-e5f4bfba9287ead3681635e7cc84cb50216134b70322c2e8734205cea5b2dd9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Callitrichinae - immunology</topic><topic>Cell Division</topic><topic>Cell Transformation, Viral</topic><topic>Cells, Cultured</topic><topic>Epstein-Barr virus</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Herpesvirus 4, Human - immunology</topic><topic>Immunity, Cellular</topic><topic>Immunologic Memory</topic><topic>Microbiology</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>Tumor Virus Infections - veterinary</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FINERTY, S</creatorcontrib><creatorcontrib>SCULLION, F. T</creatorcontrib><creatorcontrib>MORGAN, A. 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Demonstration in vitro of cell mediated immunity to Epstein-Barr virus in cotton-top tamarins</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1988-08-01</date><risdate>1988</risdate><volume>73</volume><issue>2</issue><spage>181</spage><epage>185</epage><pages>181-185</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>In the course of developing an effective Epstein-Barr (EB) virus vaccine, the immune responses in cotton-top tamarins to a tumourigenic dose of EB virus were studied. Cell mediated responses were measured using a tissue culture 'growth inhibition' assay where peripheral blood lymphocytes were tested for their ability to inhibit the outgrowth of autologous EB virus transformed lymphoblastoid cells. This system has previously been recognized as a very sensitive assay for detecting cell-mediated responses to EB virus in man. Using this assay no cell-mediated immunity was detected up to the time of death in two tamarins following injection with a tumourigenic dose of EB virus. However, two other animals which had recovered from tumours induced by a first dose of EB virus 18 months previously when subsequently re-stimulated with a second tumourigenic dose did exhibit cell-mediated responses. These latter animals remained healthy following the re-challenge and did not show evidence of EB virus-induced disease.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>2846217</pmid><tpages>5</tpages></addata></record> |
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subjects | Animals Biological and medical sciences Callitrichinae - immunology Cell Division Cell Transformation, Viral Cells, Cultured Epstein-Barr virus Fundamental and applied biological sciences. Psychology Herpesvirus 4, Human - immunology Immunity, Cellular Immunologic Memory Microbiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Tumor Virus Infections - veterinary Virology |
title | Demonstration in vitro of cell mediated immunity to Epstein-Barr virus in cotton-top tamarins |
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