Immunosuppressive effects of (2R,5R)-6-heptyne-2,5-diamine, an inhibitor of polyamine synthesis: II. Beneficial effects on the development of a lupus-like disease in MRL-lpr/lpr mice

(2R,5R)-6-heptyne-2,5-diamine (MAP; MDL 72175), a potent irreversible inhibitor of L-ornithine decarboxylase (ODC), possesses immunosuppressive activities in vitro as the result of inhibition of lymphocyte polyamine biosynthesis. The effects of MAP were now studied in vivo in MRL-lpr/lpr female mice...

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Veröffentlicht in:	Clinical and experimental immunology 1988-05, Vol.72 (2), p.293-298
Hauptverfasser:	Claverie, N, Pasquali, J L, Mamont, P S, Danzin, C, Weil-Bousson, M, Siat, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Animals Autoantibodies - biosynthesis Diamines - therapeutic use Female Immunoglobulin G - biosynthesis Immunoglobulin M - biosynthesis Kidney Glomerulus - pathology Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - pathology Lymphatic Diseases - prevention & control Mice Mice, Inbred Strains Ornithine Decarboxylase Inhibitors S-Adenosylmethionine - analogs & derivatives S-Adenosylmethionine - urine Splenomegaly - prevention & control Time Factors
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