Evidence for the presence of a receptor for IgM on the pathological cells of Sézary's syndrome
It has been demonstrated that in two patients with T-cell Sézary syndrome the pathological cells express a receptor for EA(IgM) when cultured in a medium with foetal calf or autologous serum. A study of the time-course of this rosette formation revealed that a large proportion, but not all, of E-ros...
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| Veröffentlicht in: | Clinical and experimental immunology 1978-03, Vol.31 (3), p.391-396 |
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| container_title | Clinical and experimental immunology |
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| creator | Worman, C P Burns, G F Barker, C R |
| description | It has been demonstrated that in two patients with T-cell Sézary syndrome the pathological cells express a receptor for EA(IgM) when cultured in a medium with foetal calf or autologous serum. A study of the time-course of this rosette formation revealed that a large proportion, but not all, of E-rosetting cells progressively expressed this receptor. In agreement with previous reports by others on the normal T-cell population bearing the IgM receptor, incubation at 37 degrees C in the presence of serum was shown to be a necessary condition. The implications of this pathological subpopulation of T-cells are discussed. |
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A study of the time-course of this rosette formation revealed that a large proportion, but not all, of E-rosetting cells progressively expressed this receptor. In agreement with previous reports by others on the normal T-cell population bearing the IgM receptor, incubation at 37 degrees C in the presence of serum was shown to be a necessary condition. 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A study of the time-course of this rosette formation revealed that a large proportion, but not all, of E-rosetting cells progressively expressed this receptor. In agreement with previous reports by others on the normal T-cell population bearing the IgM receptor, incubation at 37 degrees C in the presence of serum was shown to be a necessary condition. The implications of this pathological subpopulation of T-cells are discussed.</description><subject>Binding Sites</subject><subject>Cells, Cultured</subject><subject>Dermatitis, Exfoliative - immunology</subject><subject>Dermatitis, Exfoliative - pathology</subject><subject>Humans</subject><subject>Immunoglobulin M</subject><subject>Lymphatic Diseases - immunology</subject><subject>Lymphatic Diseases - pathology</subject><subject>Rosette Formation</subject><subject>Syndrome</subject><subject>T-Lymphocytes - immunology</subject><subject>Time Factors</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUEtOwzAQtRC_UrgBC69gFcl2YsfeIKGqQKUiFsDacuxxG5TGIU4rlRtxDi5GQisEq9HMe3qfOUAjmgqeMJapQzQihKhEUZKdorMY3_pVCMFO0DHNpJJ8hPR0UzqoLWAfWtwtATctxJ9D8NjgFiw0XQ8N8GzxiEO9Y5luGaqwKK2psIWqigP_-evzw7Tb64jjtnZtWME5OvKminCxn2P0ejd9mTwk86f72eR2njRMkC5JZR-YKiIFS4EqaRxPwRLpnPE59bLIjXeFz7gtwFvGjBUFYblknHunwKdjdLPTbdbFCpyFumtNpZu2XPWBdDCl_o_U5VIvwkZTnlHGVS9wtRdow_saYqdXZRyKmRrCOuo8I5SlYiBe_nX6tdh9NP0GzlB2Ag</recordid><startdate>19780301</startdate><enddate>19780301</enddate><creator>Worman, C P</creator><creator>Burns, G F</creator><creator>Barker, C R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19780301</creationdate><title>Evidence for the presence of a receptor for IgM on the pathological cells of Sézary's syndrome</title><author>Worman, C P ; Burns, G F ; Barker, C R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p260t-382241908623e198ad53ec08ddaf71f8b7afdbf45cbefc22ac6b0278255fd9ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Binding Sites</topic><topic>Cells, Cultured</topic><topic>Dermatitis, Exfoliative - immunology</topic><topic>Dermatitis, Exfoliative - pathology</topic><topic>Humans</topic><topic>Immunoglobulin M</topic><topic>Lymphatic Diseases - immunology</topic><topic>Lymphatic Diseases - pathology</topic><topic>Rosette Formation</topic><topic>Syndrome</topic><topic>T-Lymphocytes - immunology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Worman, C P</creatorcontrib><creatorcontrib>Burns, G F</creatorcontrib><creatorcontrib>Barker, C R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Worman, C P</au><au>Burns, G F</au><au>Barker, C R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for the presence of a receptor for IgM on the pathological cells of Sézary's syndrome</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1978-03-01</date><risdate>1978</risdate><volume>31</volume><issue>3</issue><spage>391</spage><epage>396</epage><pages>391-396</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><abstract>It has been demonstrated that in two patients with T-cell Sézary syndrome the pathological cells express a receptor for EA(IgM) when cultured in a medium with foetal calf or autologous serum. A study of the time-course of this rosette formation revealed that a large proportion, but not all, of E-rosetting cells progressively expressed this receptor. In agreement with previous reports by others on the normal T-cell population bearing the IgM receptor, incubation at 37 degrees C in the presence of serum was shown to be a necessary condition. The implications of this pathological subpopulation of T-cells are discussed.</abstract><cop>England</cop><pmid>148985</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Clinical and experimental immunology, 1978-03, Vol.31 (3), p.391-396 |
| issn | 0009-9104 1365-2249 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Binding Sites Cells, Cultured Dermatitis, Exfoliative - immunology Dermatitis, Exfoliative - pathology Humans Immunoglobulin M Lymphatic Diseases - immunology Lymphatic Diseases - pathology Rosette Formation Syndrome T-Lymphocytes - immunology Time Factors |
| title | Evidence for the presence of a receptor for IgM on the pathological cells of Sézary's syndrome |
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