Immunological study of patients with the Papillon--Lefevre syndrome
Papillon-Lefevre syndrome (PLS) is characterized by palmoplantar hyperkeratosis and by premature periodontal breakdown. In view of recent suggestions that this syndrome is associated with increased susceptibility to infections we decide to evaluate several immunological parameters in PLS patients an...
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| Veröffentlicht in: | Clinical and experimental immunology 1980-05, Vol.40 (2), p.407-410 |
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| creator | Levo, Y Wollner, S Hacham-Zadeh, S |
| description | Papillon-Lefevre syndrome (PLS) is characterized by palmoplantar hyperkeratosis and by premature periodontal breakdown. In view of recent suggestions that this syndrome is associated with increased susceptibility to infections we decide to evaluate several immunological parameters in PLS patients and their healthy siblings and parents. PLS patients, as well as their siblings and parents, had a significantly impaired reactivity to both T and B cell mitogens. This in vitro abnormality was not associated with increased susceptibility to infections. The relationship between the impaired in vitro response to mitogens and the predilection for dermatologic and dental manifestations of PLS is discussed. |
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In view of recent suggestions that this syndrome is associated with increased susceptibility to infections we decide to evaluate several immunological parameters in PLS patients and their healthy siblings and parents. PLS patients, as well as their siblings and parents, had a significantly impaired reactivity to both T and B cell mitogens. This in vitro abnormality was not associated with increased susceptibility to infections. The relationship between the impaired in vitro response to mitogens and the predilection for dermatologic and dental manifestations of PLS is discussed.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>PMID: 6449328</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; B-Lymphocytes - immunology ; Child ; Female ; Humans ; Immunoglobulins - analysis ; Keratoderma, Palmoplantar - immunology ; Male ; Mitogens - pharmacology ; Papillon-Lefevre Disease - genetics ; Papillon-Lefevre Disease - immunology ; Rosette Formation ; T-Lymphocytes - immunology</subject><ispartof>Clinical and experimental immunology, 1980-05, Vol.40 (2), p.407-410</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1536991/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1536991/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6449328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levo, Y</creatorcontrib><creatorcontrib>Wollner, S</creatorcontrib><creatorcontrib>Hacham-Zadeh, S</creatorcontrib><title>Immunological study of patients with the Papillon--Lefevre syndrome</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>Papillon-Lefevre syndrome (PLS) is characterized by palmoplantar hyperkeratosis and by premature periodontal breakdown. In view of recent suggestions that this syndrome is associated with increased susceptibility to infections we decide to evaluate several immunological parameters in PLS patients and their healthy siblings and parents. PLS patients, as well as their siblings and parents, had a significantly impaired reactivity to both T and B cell mitogens. This in vitro abnormality was not associated with increased susceptibility to infections. The relationship between the impaired in vitro response to mitogens and the predilection for dermatologic and dental manifestations of PLS is discussed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>B-Lymphocytes - immunology</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulins - analysis</subject><subject>Keratoderma, Palmoplantar - immunology</subject><subject>Male</subject><subject>Mitogens - pharmacology</subject><subject>Papillon-Lefevre Disease - genetics</subject><subject>Papillon-Lefevre Disease - immunology</subject><subject>Rosette Formation</subject><subject>T-Lymphocytes - immunology</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LAzEYhIMotVZ_gpCTt0C-t7kIUtQWCnroPWSzSRvJbtZNttJ_74JF9DS8vMMzw1yAOWFSIEq5ugRzjLFCimB-DW5y_phOKSWdgZnkXDG6nIPVpm3HLsW0D9ZEmMvYnGDysDcluK5k-BXKAZaDg--mDzGmDqGt8-44OJhPXTOk1t2CK29idndnXYDdy_NutUbbt9fN6mmLeipJQVIZpRRumorUS4MrVXlOBVOCCWGXzNRCUGO980RZK5loKu-wcYKommPi2QI8_mD7sW5dY6d6g4m6H0JrhpNOJuj_ny4c9D4dNRFMKkUmwMMZMKTP0eWi25Cti9F0Lo1ZV1MTTjCbjPd_k34jzquxb0U4a2A</recordid><startdate>19800501</startdate><enddate>19800501</enddate><creator>Levo, Y</creator><creator>Wollner, S</creator><creator>Hacham-Zadeh, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19800501</creationdate><title>Immunological study of patients with the Papillon--Lefevre syndrome</title><author>Levo, Y ; Wollner, S ; Hacham-Zadeh, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p261t-69a9990dd71b8a0797f425395355c83ab552acfef19cc635d7fe0ae519b401f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>B-Lymphocytes - immunology</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulins - analysis</topic><topic>Keratoderma, Palmoplantar - immunology</topic><topic>Male</topic><topic>Mitogens - pharmacology</topic><topic>Papillon-Lefevre Disease - genetics</topic><topic>Papillon-Lefevre Disease - immunology</topic><topic>Rosette Formation</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levo, Y</creatorcontrib><creatorcontrib>Wollner, S</creatorcontrib><creatorcontrib>Hacham-Zadeh, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levo, Y</au><au>Wollner, S</au><au>Hacham-Zadeh, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunological study of patients with the Papillon--Lefevre syndrome</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1980-05-01</date><risdate>1980</risdate><volume>40</volume><issue>2</issue><spage>407</spage><epage>410</epage><pages>407-410</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><abstract>Papillon-Lefevre syndrome (PLS) is characterized by palmoplantar hyperkeratosis and by premature periodontal breakdown. In view of recent suggestions that this syndrome is associated with increased susceptibility to infections we decide to evaluate several immunological parameters in PLS patients and their healthy siblings and parents. PLS patients, as well as their siblings and parents, had a significantly impaired reactivity to both T and B cell mitogens. This in vitro abnormality was not associated with increased susceptibility to infections. The relationship between the impaired in vitro response to mitogens and the predilection for dermatologic and dental manifestations of PLS is discussed.</abstract><cop>England</cop><pmid>6449328</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0009-9104 |
| ispartof | Clinical and experimental immunology, 1980-05, Vol.40 (2), p.407-410 |
| issn | 0009-9104 1365-2249 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult B-Lymphocytes - immunology Child Female Humans Immunoglobulins - analysis Keratoderma, Palmoplantar - immunology Male Mitogens - pharmacology Papillon-Lefevre Disease - genetics Papillon-Lefevre Disease - immunology Rosette Formation T-Lymphocytes - immunology |
| title | Immunological study of patients with the Papillon--Lefevre syndrome |
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